Traumatic brain injury and sleep in military and veteran populations: A literature review.

Traumatic brain injury military neuroinflammation post traumatic stress disorder sleep sleep wake disorder veteran

Journal

NeuroRehabilitation
ISSN: 1878-6448
Titre abrégé: NeuroRehabilitation
Pays: Netherlands
ID NLM: 9113791

Informations de publication

Date de publication:
02 Aug 2024
Historique:
medline: 9 8 2024
pubmed: 9 8 2024
entrez: 9 8 2024
Statut: aheadofprint

Résumé

Traumatic brain injury (TBI) is a hallmark of wartime injury and is related to numerous sleep wake disorders (SWD), which persist long term in veterans. Current knowledge gaps in pathophysiology have hindered advances in diagnosis and treatment. We reviewed TBI SWD pathophysiology, comorbidities, diagnosis and treatment that have emerged over the past two decades. We conducted a literature review of English language publications evaluating sleep disorders (obstructive sleep apnea, insomnia, hypersomnia, parasomnias, restless legs syndrome and periodic limb movement disorder) and TBI published since 2000. We excluded studies that were not specifically evaluating TBI populations. Highlighted areas of interest and knowledge gaps were identified in TBI pathophysiology and mechanisms of sleep disruption, a comparison of TBI SWD and post-traumatic stress disorder SWD. The role of TBI and glymphatic biomarkers and management strategies for TBI SWD will also be discussed. Our understanding of the pathophysiologic underpinnings of TBI and sleep health, particularly at the basic science level, is limited. Developing an understanding of biomarkers, neuroimaging, and mixed-methods research in comorbid TBI SWD holds the greatest promise to advance our ability to diagnose and monitor response to therapy in this vulnerable population.

Sections du résumé

BACKGROUND UNASSIGNED
Traumatic brain injury (TBI) is a hallmark of wartime injury and is related to numerous sleep wake disorders (SWD), which persist long term in veterans. Current knowledge gaps in pathophysiology have hindered advances in diagnosis and treatment.
OBJECTIVE UNASSIGNED
We reviewed TBI SWD pathophysiology, comorbidities, diagnosis and treatment that have emerged over the past two decades.
METHODS UNASSIGNED
We conducted a literature review of English language publications evaluating sleep disorders (obstructive sleep apnea, insomnia, hypersomnia, parasomnias, restless legs syndrome and periodic limb movement disorder) and TBI published since 2000. We excluded studies that were not specifically evaluating TBI populations.
RESULTS UNASSIGNED
Highlighted areas of interest and knowledge gaps were identified in TBI pathophysiology and mechanisms of sleep disruption, a comparison of TBI SWD and post-traumatic stress disorder SWD. The role of TBI and glymphatic biomarkers and management strategies for TBI SWD will also be discussed.
CONCLUSION UNASSIGNED
Our understanding of the pathophysiologic underpinnings of TBI and sleep health, particularly at the basic science level, is limited. Developing an understanding of biomarkers, neuroimaging, and mixed-methods research in comorbid TBI SWD holds the greatest promise to advance our ability to diagnose and monitor response to therapy in this vulnerable population.

Identifiants

DOI: 10.3233/NRE-230380 PMID: 39121144
pubmed: 39121144
pii: NRE230380
doi: 10.3233/NRE-230380
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Jeremy Landvater (J)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Sharon Kim (S)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Keenan Caswell (K)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Caroline Kwon (C)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Emamoke Odafe (E)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Grace Roe (G)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Ananya Tripathi (A)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Christian Vukovics (C)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Johnathan Wang (J)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Keith Ryan (K)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Victoria Cocozza (V)

Wilford Hall Ambulatory Surgical Center Center, San Antonio, TX, USA.

Matthew Brock (M)

Wilford Hall Ambulatory Surgical Center Center, San Antonio, TX, USA.

Zahari Tchopev (Z)

Wilford Hall Ambulatory Surgical Center Center, San Antonio, TX, USA.

Brionn Tonkin (B)

University of Minnesota, Minneapolis, MN, USA.
Minneapolis Veterans Administration Medical Center, Minneapolis, MN, USA.

Vincent Capaldi (V)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Jacob Collen (J)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Jennifer Creamer (J)

Walter Reed National Military Medical Center, Bethesda, MD, USA.

Muna Irfan (M)

University of Minnesota, Minneapolis, MN, USA.
Minneapolis Veterans Administration Medical Center, Minneapolis, MN, USA.

Emerson Wickwire (E)

Department of Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA.

Scott Williams (S)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Defense Health Headquarters, Falls Church, VA, USA.

J Kent Werner (JK)

Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Classifications MeSH