Magnesium induced structural reorganization in the active site of adenylate kinase.

Magnesium / metabolism Adenylate Kinase / metabolism Catalytic Domain Molecular Dynamics Simulation Adenosine Triphosphate / metabolism Protein Conformation Adenosine Diphosphate / metabolism

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
09 Aug 2024
Historique:
medline: 9 8 2024
pubmed: 9 8 2024
entrez: 9 8 2024
Statut: ppublish

Résumé

Phosphoryl transfer is a fundamental reaction in cellular signaling and metabolism that requires Mg

Identifiants

DOI: 10.1126/sciadv.ado5504 PMID: 39121211
pubmed: 39121211
doi: 10.1126/sciadv.ado5504
doi:

Substances chimiques

Magnesium I38ZP9992A
Adenylate Kinase EC 2.7.4.3
Adenosine Triphosphate 8L70Q75FXE
Adenosine Diphosphate 61D2G4IYVH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eado5504

Auteurs

Kwangho Nam (K)

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA.
ORCID: 0000-0003-0723-7839

Abdul Raafik Arattu Thodika (ARA)

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, USA.
ORCID: 0009-0001-4973-5265

Sonja Tischlik (S)

Department of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, 78464 Konstanz, Germany.
ORCID: 0000-0001-7518-2441

Chanrith Phoeurk (C)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
Department of Bio-Engineering, Royal University of Phnom Penh, Phnom Penh, Cambodia.
ORCID: 0000-0002-8025-4232

Tamás Milán Nagy (TM)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
ORCID: 0000-0003-4766-1992

Léon Schierholz (L)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
Department of Molecular Biology, Umeå University, Umeå, 901 87, Sweden.

Jörgen Ådén (J)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
ORCID: 0000-0002-4480-1219

Per Rogne (P)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
ORCID: 0000-0002-3687-9200

Malte Drescher (M)

Department of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, 78464 Konstanz, Germany.
ORCID: 0000-0002-3571-3452

A Elisabeth Sauer-Eriksson (AE)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
ORCID: 0000-0003-0124-0199

Magnus Wolf-Watz (M)

Department of Chemistry, Umeå University, 901 87 Umeå, Sweden.
ORCID: 0000-0002-9098-7974

Articles similaires

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.

Daipayan Sarkar, Christopher Maffeo, Markus Sutter et al.
1.00
Photosynthesis Ribulose-Bisphosphate Carboxylase Carbon Dioxide Molecular Dynamics Simulation Cyanobacteria

Trace elements in psoriasis presentation and treatment.

Pratiksha Patra, Tyler Harrison
1.00
Psoriasis Humans Magnesium Zinc Trace Elements

Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site.

Vasiliki Mavridou, Martin S King, Andre Bazzone et al.
1.00
Adenosine Triphosphate Adenosine Diphosphate Mitochondrial ADP, ATP Translocases Binding Sites Mitochondria

Drug repurposing against fucosyltransferase-2 via docking, STD-NMR, and molecular dynamic simulation studies.

Muhammad Atif, Humaira Zafar, Atia-Tul- Wahab et al.
1.00
Fucosyltransferases Drug Repositioning Molecular Docking Simulation Molecular Dynamics Simulation Humans

Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Magnésium › Magnesium induced structural reorganization in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Phosphate Group Acceptor) › Adenylate kinase › Magnesium induced structural reorganization in...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Magnesium induced structural reorganization in...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Magnesium induced structural reorganization in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Magnesium induced structural reorganization in...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Magnesium induced structural reorganization in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › ADP › Magnesium induced structural reorganization in...