Label-free, non-contact determination of resting membrane potential using dielectrophoresis.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
09 Aug 2024
Historique:
received: 06 03 2024
accepted: 30 07 2024
medline: 10 8 2024
pubmed: 10 8 2024
entrez: 9 8 2024
Statut: epublish

Résumé

Measurement of cellular resting membrane potential (RMP) is important in understanding ion channels and their role in regulation of cell function across a wide range of cell types. However, methods available for the measurement of RMP (including patch clamp, microelectrodes, and potential-sensitive fluorophores) are expensive, slow, open to operator bias, and often result in cell destruction. We present non-contact, label-free membrane potential estimation which uses dielectrophoresis to determine the cytoplasm conductivity slope as a function of medium conductivity. By comparing this to patch clamp data available in the literature, we have demonstratet the accuracy of this approach using seven different cell types, including primary suspension cells (red blood cells, platelets), cultured suspension cells (THP-1), primary adherent cells (chondrocytes, human umbilical mesenchymal stem cells), and adherent (HeLa) and suspension (Jurkat) cancer cell lines. Analysis of the effect of ion channel inhibitors suggests the effects of pharmaceutical agents (TEA on HeLa; DMSO and neuraminidase on red blood cells) can also be measured. Comparison with published values of membrane potential suggest that the differences between our estimates and values recorded by patch clamp are accurate to within published margins of error. The method is low-cost, non-destructive, operator-independent and label-free, and has previously been shown to allow cells to be recovered after measurement.

Identifiants

pubmed: 39122771
doi: 10.1038/s41598-024-69000-7
pii: 10.1038/s41598-024-69000-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

18477

Subventions

Organisme : Khalifa University of Science, Technology and Research
ID : FSU-2022-020
Organisme : Khalifa University of Science, Technology and Research,United Arab Emirates
ID : 8474000443

Informations de copyright

© 2024. The Author(s).

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Auteurs

Michael Pycraft Hughes (MP)

Department of Biomedical Engineering and Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, UAE. Michael.hughes@ku.ac.ae.
Healthcare Engineering Innovation Center, Khalifa University of Science and Technology, Abu Dhabi, UAE. Michael.hughes@ku.ac.ae.

Krista S P Clarke (KSP)

Centre for Biomedical Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Rashedul Hoque (R)

Centre for Biomedical Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Oreoluwa V Griffiths (OV)

Centre for Biomedical Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Emily J Kruchek (EJ)

Centre for Biomedical Engineering, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Matthew P Johnson (MP)

Department of Biomedical Engineering and Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, UAE.

Muhammad Hamza Tariq (MH)

Department of Biomedical Engineering and Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, UAE.

Nupur Kohli (N)

Department of Biomedical Engineering and Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, UAE.
Healthcare Engineering Innovation Center, Khalifa University of Science and Technology, Abu Dhabi, UAE.

Rebecca Lewis (R)

Department of Comparative Biomedical Sciences, School of Veterinary Medicine, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Fatima H Labeed (FH)

Department of Biology, United Arab Emirates University, Al Ain, UAE. f.labeed@uaeu.ac.ae.

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