Validity of rapid urease test using swab of gastric mucus to mucosal forceps and 13 C-urease breath test: a multicenter prospective observational study.
Humans
Breath Tests
/ methods
Helicobacter Infections
/ diagnosis
Middle Aged
Prospective Studies
Urease
/ analysis
Male
Female
Aged
Helicobacter pylori
/ isolation & purification
Adult
Aged, 80 and over
Sensitivity and Specificity
Gastric Mucosa
/ microbiology
Endoscopy, Digestive System
Reproducibility of Results
Carbon Isotopes
Surgical Instruments
/ microbiology
Helicobacter pylori
13 C-urea breath test
Atrophic gastritis
Rapid urease test
Journal
BMC gastroenterology
ISSN: 1471-230X
Titre abrégé: BMC Gastroenterol
Pays: England
ID NLM: 100968547
Informations de publication
Date de publication:
09 Aug 2024
09 Aug 2024
Historique:
received:
15
03
2024
accepted:
30
07
2024
medline:
10
8
2024
pubmed:
10
8
2024
entrez:
9
8
2024
Statut:
epublish
Résumé
Theoretically, a rapid urease test (RUT) using a swab of the gastric wall (Swab-RUT) for Helicobacter pylori (H. pylori) is safe. However, the validity and utility of Swab-RUT remain unclear. Therefore, we assessed the validity and utility of Swab-RUT compared to RUT using mucosal forceps of the gastric wall (Forceps-RUT) and This study was a multicenter prospective observational study. When the examinees were suspected of H. pylori infection during esophagogastroduodenoscopy, we performed Swab-RUT and Forceps-RUT continuously. When the examinees were not suspected of H. pylori infection, we performed Swab-RUT alone. We validated the status of H. pylori infection using UBT. Ninety-four examinees were enrolled from four institutions between May 2016 and December 2020 (median age [range], 56.5 [26-88] years). In this study, the sensitivity, specificity, and accuracy of Swab-RUT to UBT were 0.933 (95% confidence interval: 0.779-0.992), 0.922 (0.827-0.974), and 0.926 (0.853-0.970), respectively. The Kappa coefficient of Swab-RUT to UBT was 0.833, and that of Swab-RUT to forceps-RUT was 0.936. No complications were observed in this study. Swab-RUT is a valid examination for the status of H. pylori infection compared to the conventional Forceps-RUT.
Sections du résumé
BACKGROUND
BACKGROUND
Theoretically, a rapid urease test (RUT) using a swab of the gastric wall (Swab-RUT) for Helicobacter pylori (H. pylori) is safe. However, the validity and utility of Swab-RUT remain unclear. Therefore, we assessed the validity and utility of Swab-RUT compared to RUT using mucosal forceps of the gastric wall (Forceps-RUT) and
METHODS
METHODS
This study was a multicenter prospective observational study. When the examinees were suspected of H. pylori infection during esophagogastroduodenoscopy, we performed Swab-RUT and Forceps-RUT continuously. When the examinees were not suspected of H. pylori infection, we performed Swab-RUT alone. We validated the status of H. pylori infection using UBT.
RESULTS
RESULTS
Ninety-four examinees were enrolled from four institutions between May 2016 and December 2020 (median age [range], 56.5 [26-88] years). In this study, the sensitivity, specificity, and accuracy of Swab-RUT to UBT were 0.933 (95% confidence interval: 0.779-0.992), 0.922 (0.827-0.974), and 0.926 (0.853-0.970), respectively. The Kappa coefficient of Swab-RUT to UBT was 0.833, and that of Swab-RUT to forceps-RUT was 0.936. No complications were observed in this study.
CONCLUSIONS
CONCLUSIONS
Swab-RUT is a valid examination for the status of H. pylori infection compared to the conventional Forceps-RUT.
Identifiants
pubmed: 39123129
doi: 10.1186/s12876-024-03344-2
pii: 10.1186/s12876-024-03344-2
doi:
Substances chimiques
Urease
EC 3.5.1.5
Carbon Isotopes
0
Types de publication
Journal Article
Observational Study
Multicenter Study
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
258Informations de copyright
© 2024. The Author(s).
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