The Scavenging Activity of Coenzyme Q

Humans Ubiquinone / analogs & derivatives Retinal Pigment Epithelium / metabolism Oxidative Stress / drug effects Apoptosis / drug effects Hydrogen Peroxide / metabolism Mitochondria / metabolism Antioxidants / pharmacology Epithelial Cells / metabolism Cell Line Dietary Supplements
ARPE-19 DRP-1 age-related macular degeneration (AMD) caspase-3 coenzyme Q10 diabetic retinopathy (DR) mitochondrial stress oxidative stress

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
24 Jul 2024
Historique:
received: 31 05 2024
revised: 19 07 2024
accepted: 21 07 2024
medline: 10 8 2024
pubmed: 10 8 2024
entrez: 10 8 2024
Statut: epublish

Résumé

Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are common retinal diseases responsible for most blindness in working-age and elderly populations. Oxidative stress and mitochondrial dysfunction play roles in these pathogenesis, and new therapies counteracting these contributors could be of great interest. Some molecules, like coenzyme Q

Identifiants

DOI: 10.3390/ijms25158070 PMID: 39125641
pubmed: 39125641
pii: ijms25158070
doi: 10.3390/ijms25158070
pii:
doi:

Substances chimiques

Ubiquinone 1339-63-5
coenzyme Q10 EJ27X76M46
Hydrogen Peroxide BBX060AN9V
Antioxidants 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Thea Laboratories
ID : Thea Laboratories

Auteurs

Maria Hernandez (M)

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, Navarra Institute for Health Research, IdiSNA, (RICORS-TERAV), 31008 Pamplona, Spain.

Sergio Recalde (S)

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, Navarra Institute for Health Research, IdiSNA, (RICORS-TERAV), 31008 Pamplona, Spain.
ORCID: 0000-0002-9328-9725

Jaione Bezunartea (J)

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, Navarra Institute for Health Research, IdiSNA, (RICORS-TERAV), 31008 Pamplona, Spain.

Maite Moreno-Orduña (M)

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, 31008 Pamplona, Spain.

Idoia Belza (I)

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, 31008 Pamplona, Spain.

Ainara Chas-Prat (A)

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, Navarra Institute for Health Research, IdiSNA, (RICORS-TERAV), 31008 Pamplona, Spain.
ORCID: 0000-0002-5752-2112

Elena Perugini (E)

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, 31008 Pamplona, Spain.

Alfredo Garcia-Layana (A)

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, Navarra Institute for Health Research, IdiSNA, (RICORS-TERAV), 31008 Pamplona, Spain.

Patricia Fernández-Robredo (P)

Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clinica Universidad de Navarra, Navarra Institute for Health Research, IdiSNA, (RICORS-TERAV), 31008 Pamplona, Spain.
ORCID: 0000-0003-3626-6030

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Enzymes et coenzymes › Coenzymes › Ubiquinones › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Épithélium pigmentaire de la rétine › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Cellules › Cellules épithéliales › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › The Scavenging Activity of Coenzyme Q
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › The Scavenging Activity of Coenzyme Q