Anti-Neuroinflammatory Effects of

Ginkgo biloba / chemistry Microglia / drug effects Plant Extracts / pharmacology Lipopolysaccharides Animals Mice Anti-Inflammatory Agents / pharmacology Cell Line Cytokines / metabolism NF-kappa B / metabolism Neuroinflammatory Diseases / drug therapy MAP Kinase Signaling System / drug effects Ginkgo Extract
EGb 761 MAPK pathway NF-κB pathway chemokines cytokines microglia neuroinflammation

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
25 Jul 2024
Historique:
received: 29 05 2024
revised: 12 07 2024
accepted: 17 07 2024
medline: 10 8 2024
pubmed: 10 8 2024
entrez: 10 8 2024
Statut: epublish

Résumé

Inflammatory processes in the brain can exert important neuroprotective functions. However, in neurological and psychiatric disorders, it is often detrimental due to chronic microglial over-activation and the dysregulation of cytokines and chemokines. Growing evidence indicates the emerging yet prominent pathophysiological role of neuroinflammation in the development and progression of these disorders. Despite recent advances, there is still a pressing need for effective therapies, and targeting neuroinflammation is a promising approach. Therefore, in this study, we investigated the anti-neuroinflammatory potential of a marketed and quantified proprietary herbal extract of

Identifiants

DOI: 10.3390/ijms25158108 PMID: 39125680
pubmed: 39125680
pii: ijms25158108
doi: 10.3390/ijms25158108
pii:
doi:

Substances chimiques

Plant Extracts 0
Ginkgo biloba extract 19FUJ2C58T
Lipopolysaccharides 0
Anti-Inflammatory Agents 0
Cytokines 0
NF-kappa B 0
Ginkgo Extract 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : This work was supported by Dr. Willmar Schwabe GmbH & Co KG
ID : NA

Auteurs

Lu Sun (L)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Matthias Apweiler (M)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Ashwini Tirkey (A)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Dominik Klett (D)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Claus Normann (C)

Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
ORCID: 0000-0001-5693-8936

Gunnar P H Dietz (GPH)

Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
ORCID: 0000-0001-9395-8442

Martin D Lehner (MD)

Dr. Willmar Schwabe GmbH & Co. KG, Willmar-Schwabe-Straße 4, 76227 Karlsruhe, Germany.
ORCID: 0009-0001-3279-1092

Bernd L Fiebich (BL)

Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
ORCID: 0000-0002-9261-6771

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Ginkgo biloba › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Cellules › Névroglie › Microglie › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Eucaryotes › Animaux › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Maladies neuro-inflammatoires › Anti-Neuroinflammatory Effects of
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Anti-Neuroinflammatory Effects of