An Optimized Peptide Antagonist of CXCR4 Limits Survival of BCR-ABL1-Transformed Cells in Philadelphia-Chromosome-Positive B-Cell Acute Lymphoblastic Leukemia.

Receptors, CXCR4 / metabolism Fusion Proteins, bcr-abl / genetics Animals Mice Humans Peptides / pharmacology Cell Survival / drug effects Apoptosis / drug effects Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy Cell Line, Tumor Philadelphia Chromosome / drug effects Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
AMD3100 BCR–ABL1 CXCR4 EPI-X4 derivatives Imatinib cell survival

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
30 Jul 2024
Historique:
received: 16 05 2024
revised: 18 07 2024
accepted: 22 07 2024
medline: 10 8 2024
pubmed: 10 8 2024
entrez: 10 8 2024
Statut: epublish

Résumé

Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph

Identifiants

DOI: 10.3390/ijms25158306 PMID: 39125877
pubmed: 39125877
pii: ijms25158306
doi: 10.3390/ijms25158306
pii:
doi:

Substances chimiques

Receptors, CXCR4 0
Fusion Proteins, bcr-abl EC 2.7.10.2
Peptides 0
CXCR4 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : CRC1279

Auteurs

Johanna Pohl (J)

Institute of Immunology, Ulm University Medical Center, 89081 Ulm, Germany.

Angela Litz (A)

Institute of Immunology, Ulm University Medical Center, 89081 Ulm, Germany.

Omar El Ayoubi (O)

Institute of Immunology, Ulm University Medical Center, 89081 Ulm, Germany.
ORCID: 0009-0003-3204-6775

Armando Rodríguez-Alfonso (A)

Core Facility Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany.
Core Unit Mass Spectrometry and Proteomics, Ulm University Medical Center, 89081 Ulm, Germany.
ORCID: 0000-0001-5921-3770

Ludger Ständker (L)

Core Facility Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany.
ORCID: 0000-0002-8436-4260

Mirja Harms (M)

Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
ORCID: 0000-0002-5460-5166

Jan Münch (J)

Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
ORCID: 0000-0001-7316-7141

Hassan Jumaa (H)

Institute of Immunology, Ulm University Medical Center, 89081 Ulm, Germany.
ORCID: 0000-0003-3383-141X

Moumita Datta (M)

Institute of Immunology, Ulm University Medical Center, 89081 Ulm, Germany.
ORCID: 0009-0004-6524-4804

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteurs CXCR4 › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcr › Protéines de fusion bcr-abl › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Eucaryotes › Animaux › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Aberrations des chromosomes › Chromosome Philadelphie › An Optimized Peptide Antagonist of CXCR4...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Leucémie-lymphome lymphoblastique à précurseurs B › An Optimized Peptide Antagonist of CXCR4...