Prevalence and clinical implications of calcification in internal carotid artery stenosis: a retrospective study.
Humans
Carotid Stenosis
/ epidemiology
Retrospective Studies
Male
Female
Aged
Prevalence
Middle Aged
Aged, 80 and over
Carotid Artery, Internal
/ diagnostic imaging
Vascular Calcification
/ epidemiology
Plaque, Atherosclerotic
/ epidemiology
Calcinosis
/ epidemiology
Multidetector Computed Tomography
/ methods
Internal carotid artery
Ischemic stroke
Multidetector computed tomographic angiography
Plaque calcification
Positive rim sign
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
10 Aug 2024
10 Aug 2024
Historique:
received:
22
06
2023
accepted:
30
07
2024
medline:
11
8
2024
pubmed:
11
8
2024
entrez:
10
8
2024
Statut:
epublish
Résumé
Calcification is common in advanced atheromatous plaque, but its clinical significance remains unclear. This study aimed to assess the prevalence of plaque calcification in the moderate-to-severe internal carotid artery stenosis and investigate its relationship with ipsilateral ischemia. The retrospective study included 178 patients detected with proximal internal carotid artery (pICA) stenosis of ≥ 50% on multidetector computed tomography at Zhejiang Hospital from January 2019 to March 2023. Association between plaque calcification characteristics (calcification thickness, position, type, circumferential extent, calcium volume and calcium score) and ipsilateral cerebrovascular events was analyzed. The 178 patients (mean age 71.24 ± 10.02 years, 79.78% males) had 224 stenosed pICAs overall. Plaque calcification was noted in 200/224 (89.29%) arteries. Calcification rates were higher in older age-groups. Calcification volume (r = 0.219, p < 0.001) and calcification score (r = 0.230, p < 0.001) were correlated with age. Ipsilateral ischemic events were significantly more common in the noncalcification group than in the calcification group (χ Plaque calcification in proximal internal carotid artery is common, and prevalence increases with age. Calcification characteristics could be predictive of ipsilateral ischemic events. The positive rim sign within plaque is a high-risk factor for a future ischemic event.
Sections du résumé
BACKGROUND
BACKGROUND
Calcification is common in advanced atheromatous plaque, but its clinical significance remains unclear. This study aimed to assess the prevalence of plaque calcification in the moderate-to-severe internal carotid artery stenosis and investigate its relationship with ipsilateral ischemia.
METHODS
METHODS
The retrospective study included 178 patients detected with proximal internal carotid artery (pICA) stenosis of ≥ 50% on multidetector computed tomography at Zhejiang Hospital from January 2019 to March 2023. Association between plaque calcification characteristics (calcification thickness, position, type, circumferential extent, calcium volume and calcium score) and ipsilateral cerebrovascular events was analyzed.
RESULTS
RESULTS
The 178 patients (mean age 71.24 ± 10.02 years, 79.78% males) had 224 stenosed pICAs overall. Plaque calcification was noted in 200/224 (89.29%) arteries. Calcification rates were higher in older age-groups. Calcification volume (r = 0.219, p < 0.001) and calcification score (r = 0.230, p < 0.001) were correlated with age. Ipsilateral ischemic events were significantly more common in the noncalcification group than in the calcification group (χ
CONCLUSIONS
CONCLUSIONS
Plaque calcification in proximal internal carotid artery is common, and prevalence increases with age. Calcification characteristics could be predictive of ipsilateral ischemic events. The positive rim sign within plaque is a high-risk factor for a future ischemic event.
Identifiants
pubmed: 39127616
doi: 10.1186/s12883-024-03788-9
pii: 10.1186/s12883-024-03788-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
279Subventions
Organisme : Medical Science and Technology Project of Zhejiang Province
ID : NO.2022KY468
Organisme : Medical Science and Technology Project of Zhejiang Province
ID : NO.2022KY484
Organisme : Key Research and Development Project of Zhejiang Provincial Department of Science and Technology
ID : NO.2021C03105
Organisme : Special Support Program for High Level Talents of Zhejiang Province
ID : NO.2022R52038
Informations de copyright
© 2024. The Author(s).
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