The StPti5 ethylene response factor acts as a susceptibility factor by negatively regulating the potato immune response to pathogens.
Pti5
Ralstonia solanacearum
Solanum tuberosum (potato)
ethylene response factor
immune signalling
potato virus Y (PVY)
susceptibility factor
Journal
The New phytologist
ISSN: 1469-8137
Titre abrégé: New Phytol
Pays: England
ID NLM: 9882884
Informations de publication
Date de publication:
11 Aug 2024
11 Aug 2024
Historique:
received:
27
02
2024
accepted:
02
07
2024
medline:
12
8
2024
pubmed:
12
8
2024
entrez:
11
8
2024
Statut:
aheadofprint
Résumé
Ethylene response factors (ERFs) have been associated with biotic stress in Arabidopsis, while their function in non-model plants is still poorly understood. Here we investigated the role of potato ERF StPti5 in plant immunity. We show that StPti5 acts as a susceptibility factor. It negatively regulates potato immunity against potato virus Y and Ralstonia solanacearum, pathogens with completely different modes of action, and thereby has a different role than its orthologue in tomato. Remarkably, StPti5 is destabilised in healthy plants via the autophagy pathway and accumulates exclusively in the nucleus upon infection. We demonstrate that StEIN3 and StEIL1 directly bind the StPti5 promoter and activate its expression, while synergistic activity of the ethylene and salicylic acid pathways is required for regulated StPti expression. To gain further insight into the mode of StPti5 action in attenuating potato defence responses, we investigated transcriptional changes in salicylic acid deficient potato lines with silenced StPti5 expression. We show that StPti5 regulates the expression of other ERFs and downregulates the ubiquitin-proteasome pathway as well as several proteases involved in directed proteolysis. This study adds a novel element to the complex puzzle of immune regulation, by deciphering a two-level regulation of ERF transcription factor activity in response to pathogens.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : J1-2467
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : J1-4268
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : J4-1777
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : J4-7636
Organisme : Javna Agencija za Raziskovalno Dejavnost RS
ID : P4-0165
Organisme : The European Cooperation in Science and Technology (COST)
ID : CA15223
Organisme : The European Cooperation in Science and Technology (COST)
ID : FA1405
Informations de copyright
© 2024 The Author(s). New Phytologist © 2024 New Phytologist Foundation.
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