Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f.
ANO1
ANO6
Anoctamin 1
Anoctamin 6
Ca2+-Activated Cl− Channel
Exocytosis
Goblet Cells
Paneth Cells
Phospholipid Scrambling
Secretion
TMEM16A
TMEM16F
Journal
Gastro hep advances
ISSN: 2772-5723
Titre abrégé: Gastro Hep Adv
Pays: Netherlands
ID NLM: 9918350485906676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
05
2022
accepted:
03
08
2022
medline:
7
8
2022
pubmed:
7
8
2022
entrez:
12
8
2024
Statut:
epublish
Résumé
Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn. The calcium-activated chloride channel TMEM16A and the phospholipid scramblase TMEM16F control intracellular Ca Mice with intestinal epithelial knockout of Tmem16a (Tmem16a Paneth cells in the crypts of Lieberkuhn from Tmem16a The present data demonstrate the role of Tmem16 for exocytosis in Paneth cells. Inhibition or activation of Tmem16a/f is likely to affect microbial content and immune functions present in the small intestine.
Sections du résumé
Background and Aims
UNASSIGNED
Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn. The calcium-activated chloride channel TMEM16A and the phospholipid scramblase TMEM16F control intracellular Ca
Methods
UNASSIGNED
Mice with intestinal epithelial knockout of Tmem16a (Tmem16a
Results
UNASSIGNED
Paneth cells in the crypts of Lieberkuhn from Tmem16a
Conclusion
UNASSIGNED
The present data demonstrate the role of Tmem16 for exocytosis in Paneth cells. Inhibition or activation of Tmem16a/f is likely to affect microbial content and immune functions present in the small intestine.
Identifiants
pubmed: 39131261
doi: 10.1016/j.gastha.2022.08.002
pii: S2772-5723(22)00139-X
pmc: PMC11308424
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1088-1098Informations de copyright
© 2022 Published by Elsevier Inc. on behalf of the AGA Institute.