Mechanism of neurodegeneration mediated by clonal inflammatory microglia.

Journal

bioRxiv : the preprint server for biology

ISSN: 2692-8205

Titre abrégé: bioRxiv

Pays: United States

ID NLM: 101680187

Informations de publication

Date de publication:
31 Jul 2024

Historique:

medline: 12 8 2024

pubmed: 12 8 2024

entrez: 12 8 2024

Statut: epublish

Résumé

Langerhans cell Histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders, associated with MAP-Kinase activating mutations and an increased risk of neurodegeneration. Surprisingly, we found pervasive PU.1

Identifiants

DOI: 10.1101/2024.07.30.605867 PMID: 39131366 PMC: PMC11312538

pubmed: 39131366

doi: 10.1101/2024.07.30.605867

pmc: PMC11312538

pii:

doi:

Types de publication

Journal Article Preprint

Langues

eng