CEST effect of dimethyl sulfoxide at negative offset frequency.
CEST
DMSO
drug delivery
rNOE
Journal
NMR in biomedicine
ISSN: 1099-1492
Titre abrégé: NMR Biomed
Pays: England
ID NLM: 8915233
Informations de publication
Date de publication:
12 Aug 2024
12 Aug 2024
Historique:
revised:
22
07
2024
received:
04
10
2023
accepted:
25
07
2024
medline:
13
8
2024
pubmed:
13
8
2024
entrez:
12
8
2024
Statut:
aheadofprint
Résumé
Dimethyl sulfoxide (DMSO) has wide biomedical applications such as cryoprotectant and hydrophobic drug carrier. Here, we report for the first time that DMSO can generate a distinctive chemical exchange saturation transfer (CEST) signal at around -2 ppm. Structural analogs of DMSO, including aprotic and protic solvents, also demonstrated CEST signals from -1.4 to -3.8 ppm. When CEST detectable barbituric acid (BA) was dissolved in DMSO solution and was co-loaded to liposome, two obvious peaks at 5 and -2 ppm were observed, indicating that DMSO and related solvent system can be monitored in a label-free manner via CEST, which can be further applied to imaging drug nanocarriers. With reference to previous studies, there could be molecular interactions or magnetization transfer pathways, such as the relayed nuclear Overhauser enhancement (rNOE), that lead to this detectable CEST contrast at negative offset frequencies of the Z-spectrum. Our findings suggest that small molecules of organic solvents could be involved in magnetization transfer processes with water and readily detected by CEST magnetic resonance imaging (MRI), providing a new avenue for detecting solvent-water and solvent-drug interactions.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e5238Subventions
Organisme : Research Grants Council
ID : 11200422
Organisme : Research Grants Council
ID : RFS2223-1S02
Organisme : Research Grants Council
ID : PDFS2122-1S01
Organisme : Research Grants Council
ID : C1134-20G
Organisme : City University of Hong Kong
ID : 7005433
Organisme : City University of Hong Kong
ID : 7005626
Organisme : City University of Hong Kong
ID : 9609307
Organisme : City University of Hong Kong
ID : 9610616
Organisme : National Natural Science Foundation of China
ID : 81871409
Organisme : Tung Biomedical Sciences Centre (TBSC)
Organisme : Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE)
Informations de copyright
© 2024 The Author(s). NMR in Biomedicine published by John Wiley & Sons Ltd.
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