GENETIC DETERMINANTS OF THROMBOSIS.

Humans Genome-Wide Association Study Genetic Predisposition to Disease Risk Factors Venous Thromboembolism / genetics Phenotype Thrombosis / genetics Blood Coagulation / genetics

Journal

Transactions of the American Clinical and Climatological Association
ISSN: 0065-7778
Titre abrégé: Trans Am Clin Climatol Assoc
Pays: United States
ID NLM: 7507559

Informations de publication

Date de publication:
2024
Historique:
medline: 13 8 2024
pubmed: 13 8 2024
entrez: 13 8 2024
Statut: ppublish

Résumé

Venous thromboembolism (VTE) is a major cause of morbidity and mortality in the United States. VTE is caused by genetic and acquired conditions, but the genetic variants that increase the risk of VTE are not fully characterized. Recent genome-wide association studies (GWAS) have discovered novel genetic loci linked to VTE. Some of these loci have been characterized, uncovering new pathways that regulate VTE. Functional characterization of candidate genes discovered by GWAS may reveal new therapeutic targets to treat and prevent abnormal thrombosis or bleeding.

Identifiants

PMID: 39135563 PMC: PMC11316864
pubmed: 39135563
pmc: PMC11316864

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

230-238

Informations de copyright

© 2024 The American Clinical and Climatological Association.

Auteurs

Charles J Lowenstein (CJ)

BALTIMORE, MARYLAND.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › GENETIC DETERMINANTS OF THROMBOSIS.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › GENETIC DETERMINANTS OF THROMBOSIS.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › GENETIC DETERMINANTS OF THROMBOSIS.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › GENETIC DETERMINANTS OF THROMBOSIS.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thromboembolie › Thromboembolisme veineux › GENETIC DETERMINANTS OF THROMBOSIS.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › GENETIC DETERMINANTS OF THROMBOSIS.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › GENETIC DETERMINANTS OF THROMBOSIS.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Coagulation sanguine › GENETIC DETERMINANTS OF THROMBOSIS.