Regulation of the Lewis Blood Group Antigen Expression: A Literature Review Supplemented with Computational Analysis.
Gene regulation
Lewis blood group
Transcription
Transcription factors
Translation
Journal
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
ISSN: 1660-3796
Titre abrégé: Transfus Med Hemother
Pays: Switzerland
ID NLM: 101176417
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
27
11
2023
accepted:
11
04
2024
medline:
13
8
2024
pubmed:
13
8
2024
entrez:
13
8
2024
Statut:
epublish
Résumé
The Lewis (Le) blood group system, unlike most other blood groups, is not defined by antigens produced internally to the erythrocytes and their precursors but rather by glycan antigens adsorbed on to the erythrocyte membrane from the plasma. These oligosaccharides are synthesized by the two fucosyltransferases To address this question, we screened existing literature and additionally used in silico prediction tools to identify novel candidate regulators for Understanding the regulation of The Lewis (Le) blood group system, in contrast to the majority of blood groups, is not able to synthesize its antigens itself. It depends on the attachment of different oligosaccharides to the erythrocyte membrane, which are adsorbed from the plasma. These glycans are modified by the fucosyltransferases 2 and 3 enzymes (FUT2/3). Beside their role in defining the Lewis blood group, FUT2 and FUT3 are also known to be involved in the susceptibility and progression of various gastrointestinal pathologies, like inflammatory bowel diseases (IBD) or colorectal cancer (CRC). Even though different expression levels of
Sections du résumé
Background
UNASSIGNED
The Lewis (Le) blood group system, unlike most other blood groups, is not defined by antigens produced internally to the erythrocytes and their precursors but rather by glycan antigens adsorbed on to the erythrocyte membrane from the plasma. These oligosaccharides are synthesized by the two fucosyltransferases
Summary
UNASSIGNED
To address this question, we screened existing literature and additionally used in silico prediction tools to identify novel candidate regulators for
Key Messages
UNASSIGNED
Understanding the regulation of
The Lewis (Le) blood group system, in contrast to the majority of blood groups, is not able to synthesize its antigens itself. It depends on the attachment of different oligosaccharides to the erythrocyte membrane, which are adsorbed from the plasma. These glycans are modified by the fucosyltransferases 2 and 3 enzymes (FUT2/3). Beside their role in defining the Lewis blood group, FUT2 and FUT3 are also known to be involved in the susceptibility and progression of various gastrointestinal pathologies, like inflammatory bowel diseases (IBD) or colorectal cancer (CRC). Even though different expression levels of
Autres résumés
Type: plain-language-summary
(eng)
The Lewis (Le) blood group system, in contrast to the majority of blood groups, is not able to synthesize its antigens itself. It depends on the attachment of different oligosaccharides to the erythrocyte membrane, which are adsorbed from the plasma. These glycans are modified by the fucosyltransferases 2 and 3 enzymes (FUT2/3). Beside their role in defining the Lewis blood group, FUT2 and FUT3 are also known to be involved in the susceptibility and progression of various gastrointestinal pathologies, like inflammatory bowel diseases (IBD) or colorectal cancer (CRC). Even though different expression levels of
Identifiants
pubmed: 39135855
doi: 10.1159/000538863
pii: 538863
pmc: PMC11318966
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
225-236Informations de copyright
© 2024 The Author(s). Published by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
C.G. acts as a consultant to Inno-Train GmbH, Kronberg im Taunus, Germany, a provider of genotyping kits for molecular blood group diagnostics since 1998 and holds the European and US patents P3545102 and US20190316189 on the “determination of the genotype underlying the S-s-U-phenotype of the MNSs blood group system.” All other authors state no conflict of interest.