National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study.
biobank
focal segmental glomerulosclerosis
idiopathic nephrotic syndrome
minimal change disease
Journal
Clinical kidney journal
ISSN: 2048-8505
Titre abrégé: Clin Kidney J
Pays: England
ID NLM: 101579321
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
29
01
2024
medline:
13
8
2024
pubmed:
13
8
2024
entrez:
13
8
2024
Statut:
epublish
Résumé
Idiopathic nephrotic syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS cohort aims to facilitate novel ways of stratifying INS patients to improve disease understanding, therapeutics and design of clinical trials. NURTuRE-INS is a prospective cohort study of children and adults with INS in a linked biorepository. All recruits had at least one sampling visit collecting serum, plasma, urine and blood for RNA and DNA extraction, frozen within 2 hours of collection. Clinical histology slides and biopsy tissue blocks were also collected. A total of 739 participants were recruited from 23 centres to NURTuRE-INS, half of whom were diagnosed in childhood [ NURTuRE-INS is a prospective cohort study with high-quality biosamples and longitudinal data that will assist research into the mechanistic stratification of INS. Samples and data will be available through a Strategic Access and Oversight Committee.
Sections du résumé
Background
UNASSIGNED
Idiopathic nephrotic syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS cohort aims to facilitate novel ways of stratifying INS patients to improve disease understanding, therapeutics and design of clinical trials.
Methods
UNASSIGNED
NURTuRE-INS is a prospective cohort study of children and adults with INS in a linked biorepository. All recruits had at least one sampling visit collecting serum, plasma, urine and blood for RNA and DNA extraction, frozen within 2 hours of collection. Clinical histology slides and biopsy tissue blocks were also collected.
Results
UNASSIGNED
A total of 739 participants were recruited from 23 centres to NURTuRE-INS, half of whom were diagnosed in childhood [
Conclusions
UNASSIGNED
NURTuRE-INS is a prospective cohort study with high-quality biosamples and longitudinal data that will assist research into the mechanistic stratification of INS. Samples and data will be available through a Strategic Access and Oversight Committee.
Identifiants
pubmed: 39135942
doi: 10.1093/ckj/sfae096
pii: sfae096
pmc: PMC11317841
doi:
Types de publication
Journal Article
Langues
eng
Pagination
sfae096Informations de copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.
Déclaration de conflit d'intérêts
M.W.T. reports consulting fees from Boehringer Ingelheim, honoraria and support to attend conferences from Bayer and a leadership role in the International Society of Nephrology. M.A.S. reports consulting fees from Travere and Purespring Therapeutics. R.E.B. reports grant funding and a patent with Randox Laboratories and support for attending meetings from Kidney Research UK. T.J. reports previous salary from UCB, consulting fees from UCB and Hybridize Therapeutics and shares in UCB. M.N reports a position on the QUOD Steering Committee. R.U. reports consulting fees from and stock in AstraZeneca and a leadership position in the Faculty of Pharmaceutical Medicine, Royal College of Physicians (London). The other authors declare that they have no competing interests.