Circular RNA as a Biomarker for Diagnosis, Prognosis and Therapeutic Target in Acute and Chronic Lymphoid Leukemia.
Acute lymphoid leukemia
Chronic lymphoid leukemia
CircRNA
Diagnosis
Treatment
miRNA
Journal
Cell biochemistry and biophysics
ISSN: 1559-0283
Titre abrégé: Cell Biochem Biophys
Pays: United States
ID NLM: 9701934
Informations de publication
Date de publication:
13 Aug 2024
13 Aug 2024
Historique:
accepted:
03
07
2024
medline:
13
8
2024
pubmed:
13
8
2024
entrez:
13
8
2024
Statut:
aheadofprint
Résumé
Circular RNAs (circRNAs) are single-stranded RNAs that have received much attention in recent years. CircRNAs lack a 5' head and a 3' poly-A tail. The structure of this type of RNAs make them resistant to digestion by exonucleases. CircRNAs are expressed in different cells and have various functions. The function of circRNAs is done by sponging miRNAs, changing gene expression, and protein production. The expression of circRNAs changes in different types of cancers, which causes changes in cell growth, proliferation, differentiation, and apoptosis. Changes in the expression of circRNAs can cause the invasion and progression of tumors. Studies have shown that changes in the expression of circRNAs can be seen in acute lymphoid leukemia (ALL) and chronic lymphoid leukemia (CLL). The conducted studies aim to identify circRNAs whose expression has changed in these leukemias and their more precise function so that these circRNAs can be identified as biomarkers, prediction of patient prognosis, and treatment targets for ALL and CLL patients. In this study, we review the studies conducted on the role and function of circRNAs in ALL and CLL patients. The results of the studies show that there is a possibility of using circRNAs as biomarkers in the identification and treatment of patients in the future.
Identifiants
pubmed: 39136839
doi: 10.1007/s12013-024-01404-8
pii: 10.1007/s12013-024-01404-8
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deanship of Scientific Research, King Khalid University
ID : R.G.P.2/315/44
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Khodakarami, A., Adibfar, S., Karpisheh, V., Abolhasani, S., Jalali, P., & Mohammadi, H., et al. (2022). The molecular biology and therapeutic potential of Nrf2 in leukemia. Cancer Cell International, 22(1), 241.
pubmed: 35906617
pmcid: 9336077
doi: 10.1186/s12935-022-02660-5
Pui, C.-H. (1995). Childhood Leukemias. New England Journal of Medicine, 332(24), 1618–1630.
pubmed: 7753142
doi: 10.1056/NEJM199506153322407
Banjar, H., Adelson, D., Brown, F., & Chaudhri, N. (2017). Intelligent techniques using molecular data analysis in leukaemia: an opportunity for personalized medicine support system. Biomed Research International, 2017, 3587309.
pubmed: 28812013
pmcid: 5547708
doi: 10.1155/2017/3587309
Tran, T., Vununu, C., Atoev, S., Lee, S.-H., & Kwon, K.-R. (2018). Leukemia blood cell image classification using convolutional neural network. International Journal of Computer Theory and Engineering, 10, 54–58.
doi: 10.7763/IJCTE.2018.V10.1198
Bhat, A. A., Younes, S. N., Raza, S. S., Zarif, L., Nisar, S., & Ahmed, I., et al. (2020). Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance. Molecular Cancer, 19(1), 57.
pubmed: 32164715
pmcid: 7069174
doi: 10.1186/s12943-020-01175-9
Deng, W., Chao, R., & Zhu, S. (2023). Emerging roles of circRNAs in leukemia and the clinical prospects: An update. Immunity, Inflammation and Diseases, 11(1), e725.
doi: 10.1002/iid3.725
Perez de Acha, O., Rossi, M., & Gorospe, M. (2020). Circular RNAs in blood malignancies. Frontiers in Molecular Biosciences, 7, 109.
pubmed: 32676504
pmcid: 7333357
doi: 10.3389/fmolb.2020.00109
Rüchel, N., Jepsen, V. H., Hein, D., Fischer, U., Borkhardt, A., & Gössling, K. L. (2022). In utero development and immunosurveillance of B cell acute lymphoblastic leukemia. Current Treatment Options in Oncology, 23(4), 543–561.
pubmed: 35294722
pmcid: 8924576
doi: 10.1007/s11864-022-00963-3
Scheffold, A., & Stilgenbauer, S. (2020). Revolution of chronic lymphocytic leukemia therapy: The chemo-free treatment paradigm. Current Oncology Report, 22(2), 16.
doi: 10.1007/s11912-020-0881-4
Medinger, M., Lengerke, C., & Passweg, J. (2016). Novel therapeutic options in acute myeloid leukemia. Leukemia Research Report, 6, 39–49.
doi: 10.1016/j.lrr.2016.09.001
Jadidi-Niaragh, F., Ghalamfarsa, G., Yousefi, M., Tabrizi, M. H., & Shokri, F. (2013). Regulatory T cells in chronic lymphocytic leukemia: Implication for immunotherapeutic interventions. Tumour Biology, 34(4), 2031–2039.
pubmed: 23681798
doi: 10.1007/s13277-013-0832-x
Coiffier, B., Altman, A., Pui, C. H., Younes, A., & Cairo, M. S. (2008). Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. Journal of Clinical Oncology, 26(16), 2767–2778.
pubmed: 18509186
doi: 10.1200/JCO.2007.15.0177
Jeck, W. R., & Sharpless, N. E. (2014). Detecting and characterizing circular RNAs. Nature Biotechnology, 32(5), 453–461.
pubmed: 24811520
pmcid: 4121655
doi: 10.1038/nbt.2890
Solé, C., Lawrie, C. (2020). Circular RNAs and cancer: Opportunities and challenges. Advances in Clinical Chemistry, 99, 87−146.
Gaffo, E., Boldrin, E., Dal Molin, A., Bresolin, S., Bonizzato, A., & Trentin, L., et al. (2019). Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. Scientific Reports, 9(1), 14670.
pubmed: 31605010
pmcid: 6789028
doi: 10.1038/s41598-019-50864-z
Li, Q., Ren, X., Wang, Y., & Xin, X. (2023). CircRNA: a rising star in leukemia. PeerJ, 11, e15577.
pubmed: 37431465
pmcid: 10329819
doi: 10.7717/peerj.15577
Tang, X., Ren, H., Guo, M., Qian, J., Yang, Y., & Gu, C. (2021). Review on circular RNAs and new insights into their roles in cancer. Computational and Structural Biotechnology Journal, 19, 910–928.
pubmed: 33598105
pmcid: 7851342
doi: 10.1016/j.csbj.2021.01.018
Zheng, X., Chen, L., Zhou, Y., Wang, Q., Zheng, Z., & Xu, B., et al. (2019). A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling. Molecular Cancer, 18(1), 47.
pubmed: 30925892
pmcid: 6440158
doi: 10.1186/s12943-019-1010-6
Conn, S. J., Pillman, K. A., Toubia, J., Conn, V. M., Salmanidis, M., & Phillips, C. A., et al. (2015). The RNA binding protein quaking regulates formation of circRNAs. Cell, 160(6), 1125–1134.
pubmed: 25768908
doi: 10.1016/j.cell.2015.02.014
Errichelli, L., Dini Modigliani, S., Laneve, P., Colantoni, A., Legnini, I., & Capauto, D., et al. (2017). FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Nature Communications, 8(1), 14741.
pubmed: 28358055
pmcid: 5379105
doi: 10.1038/ncomms14741
Ivanov, A., Memczak, S., Wyler, E., Torti, F., Porath, H. T., & Orejuela, M. R., et al. (2015). Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Cell Reports, 10(2), 170–177.
pubmed: 25558066
doi: 10.1016/j.celrep.2014.12.019
Liang, D., & Wilusz, J. E. (2014). Short intronic repeat sequences facilitate circular RNA production. Genes and Development, 28(20), 2233–2247.
pubmed: 25281217
pmcid: 4201285
doi: 10.1101/gad.251926.114
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., & Hanan, M., et al. (2014). circRNA biogenesis competes with pre-mRNA splicing. Molecular Cell, 56(1), 55–66.
pubmed: 25242144
doi: 10.1016/j.molcel.2014.08.019
Kelly, S., Greenman, C., Cook, P. R., & Papantonis, A. (2015). Exon skipping is correlated with exon circularization. Journal of Molecular Biology, 427(15), 2414–2417.
pubmed: 25728652
doi: 10.1016/j.jmb.2015.02.018
Noto, J. J., Schmidt, C. A., & Matera, A. G. (2017). Engineering and expressing circular RNAs via tRNA splicing. RNA Biology, 14(8), 978–984.
pubmed: 28402213
pmcid: 5680671
doi: 10.1080/15476286.2017.1317911
Du, W. W., Yang, W., Liu, E., Yang, Z., Dhaliwal, P., & Yang, B. B. (2016). Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Research, 44(6), 2846–2858.
pubmed: 26861625
pmcid: 4824104
doi: 10.1093/nar/gkw027
Piwecka, M., Glažar, P., Hernandez-Miranda, L. R., Memczak, S., Wolf, S. A., & Rybak-Wolf, A., et al. (2017). Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science, 357(6357), eaam8526.
pubmed: 28798046
doi: 10.1126/science.aam8526
Kohlhapp, F. J., Mitra, A. K., Lengyel, E., & Peter, M. E. (2015). MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment. Oncogene, 34(48), 5857–5868.
pubmed: 25867073
pmcid: 4604012
doi: 10.1038/onc.2015.89
Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., & Clark, S. J., et al. (2011). miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. Embo Journal, 30(21), 4414–4422.
pubmed: 21964070
pmcid: 3230379
doi: 10.1038/emboj.2011.359
van Rossum, D., Verheijen, B. M., & Pasterkamp, R. J. (2016). Circular RNAs: Novel regulators of neuronal development. Frontiers in Molecular Neuroscience, 9, 74.
pubmed: 27616979
pmcid: 4999478
Yang, Y., Fan, X., Mao, M., Song, X., Wu, P., & Zhang, Y., et al. (2017). Extensive translation of circular RNAs driven by N(6)-methyladenosine. Cell Research, 27(5), 626–641.
pubmed: 28281539
pmcid: 5520850
doi: 10.1038/cr.2017.31
Yang, Y., Gao, X., Zhang, M., Yan, S., Sun, C., & Xiao, F., et al. (2018). Novel role of FBXW7 Circular RNA in repressing glioma tumorigenesis. Journal of the National Cancer Institute, 110(3), 304–315.
pubmed: 28903484
doi: 10.1093/jnci/djx166
Wesselhoeft, R. A., Kowalski, P. S., & Anderson, D. G. (2018). Engineering circular RNA for potent and stable translation in eukaryotic cells. Nature Communications, 9(1), 2629.
pubmed: 29980667
pmcid: 6035260
doi: 10.1038/s41467-018-05096-6
Wang, S., Su, T., Tong, H., Zhou, D., Ma, F., & Ding, J., et al. (2021). Circβ-catenin promotes tumor growth and Warburg effect of gallbladder cancer by regulating STMN1 expression. Cell Death Discovery, 7(1), 233.
pubmed: 34489401
pmcid: 8421404
doi: 10.1038/s41420-021-00626-6
Xia, X., Li, X., Li, F., Wu, X., Zhang, M., & Zhou, H., et al. (2019). A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1. Molecular Cancer, 18(1), 131.
pubmed: 31470874
pmcid: 6716823
doi: 10.1186/s12943-019-1056-5
Dong, R., Zhang, X.-O., Zhang, Y., Ma, X.-K., Chen, L.-L., & Yang, L. (2016). CircRNA-derived pseudogenes. Cell Research, 26(6), 747–750.
pubmed: 27021280
pmcid: 4897178
doi: 10.1038/cr.2016.42
Li, Z., Huang, C., Bao, C., Chen, L., Lin, M., & Wang, X., et al. (2015). Exon-intron circular RNAs regulate transcription in the nucleus. Nature Structural & Molecular Biology, 22(3), 256–264.
doi: 10.1038/nsmb.2959
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., & Liu, J., et al. (2013). Circular RNAs are abundant, conserved, and associated with ALU repeats. Rna, 19(2), 141–157.
pubmed: 23249747
pmcid: 3543092
doi: 10.1261/rna.035667.112
Lasda, E., & Parker, R. (2016). Circular RNAs Co-precipitate with extracellular vesicles: a possible mechanism for circRNA clearance. PLoS One, 11(2), e0148407.
pubmed: 26848835
pmcid: 4743949
doi: 10.1371/journal.pone.0148407
Preußer, C., Hung, L. H., Schneider, T., Schreiner, S., Hardt, M., & Moebus, A., et al. (2018). Selective release of circRNAs in platelet-derived extracellular vesicles. Journal of Extracellular Vesicles, 7(1), 1424473.
pubmed: 29359036
pmcid: 5769804
doi: 10.1080/20013078.2018.1424473
Gong, L., Zhou, X., & Sun, J. (2021). Circular RNAs interaction with MiRNAs: Emerging roles in breast cancer. International Journal of Medical Sciences, 18(14), 3182–3196.
pubmed: 34400888
pmcid: 8364445
doi: 10.7150/ijms.62219
He, A. T., Liu, J., Li, F., & Yang, B. B. (2021). Targeting circular RNAs as a therapeutic approach: current strategies and challenges. Signal Transduction and Targeted Therapy, 6(1), 185.
pubmed: 34016945
pmcid: 8137869
doi: 10.1038/s41392-021-00569-5
Awan, F. M., Yang, B. B., Naz, A., Hanif, A., Ikram, A., & Obaid, A., et al. (2021). The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents. RNA Biology, 18(1), 1–15.
pubmed: 32615049
doi: 10.1080/15476286.2020.1790198
Han, D., Wang, Y., Wang, Y., Dai, X., Zhou, T., & Chen, J., et al. (2020). The tumor-suppressive human circular RNA CircITCH sponges miR-330-5p to ameliorate doxorubicin-induced cardiotoxicity through upregulating SIRT6, Survivin, and SERCA2a. Circulation Research, 127(4), e108–e125.
pubmed: 32392088
doi: 10.1161/CIRCRESAHA.119.316061
Holdt, L. M., Kohlmaier, A., & Teupser, D. (2018). Circular RNAs as therapeutic agents and targets. Frontiers in Physiology, 9, 1262.
pubmed: 30356745
pmcid: 6189416
doi: 10.3389/fphys.2018.01262
Wu, N., Xu, J., Du, W. W., Li, X., Awan, F. M., & Li, F., et al. (2021). YAP circular RNA, circYap, attenuates cardiac fibrosis via binding with Tropomyosin-4 and Gamma-Actin decreasing actin polymerization. Molecular Therapy, 29(3), 1138–1150.
pubmed: 33279723
doi: 10.1016/j.ymthe.2020.12.004
Yang, L., Han, B., Zhang, Z., Wang, S., Bai, Y., & Zhang, Y., et al. (2020). Extracellular vesicle-mediated delivery of circular RNA SCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models. Circulation, 142(6), 556–574.
pubmed: 32441115
doi: 10.1161/CIRCULATIONAHA.120.045765
Jiang, Q., Liu, C., Li, C. P., Xu, S. S., Yao, M. D., & Ge, H. M., et al. (2020). Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction. Journal of Clinical Investigation, 130(7), 3833–3847.
pubmed: 32343678
pmcid: 7324174
doi: 10.1172/JCI123353
Li, S., Li, X., Xue, W., Zhang, L., Yang, L.-Z., & Cao, S.-M., et al. (2021). Screening for functional circular RNAs using the CRISPR–Cas13 system. Nature Methods, 18(1), 51–59.
pubmed: 33288960
doi: 10.1038/s41592-020-01011-4
Zhang, Y., Nguyen, T. M., Zhang, X. O., Wang, L., Phan, T., & Clohessy, J. G., et al. (2021). Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs. Genome Biology, 22(1), 41.
pubmed: 33478577
pmcid: 7818937
doi: 10.1186/s13059-021-02263-9
Duan, Y., Dong, X., Nie, J., Li, P., Lu, F., & Ma, D., et al. (2018). Wee1 kinase inhibitor MK-1775 induces apoptosis of acute lymphoblastic leukemia cells and enhances the efficacy of doxorubicin involving downregulation of Notch pathway. Oncology Letters, 16(4), 5473–5481.
pubmed: 30250620
pmcid: 6144465
Hunger, S. P., & Mullighan, C. G. (2015). Acute lymphoblastic leukemia in children. New England Journal of Medicine, 373(16), 1541–1552.
pubmed: 26465987
doi: 10.1056/NEJMra1400972
Eckert, C., von Stackelberg, A., Seeger, K., Groeneveld, T. W. L., Peters, C., & Klingebiel, T., et al. (2013). Minimal residual disease after induction is the strongest predictor of prognosis in intermediate risk relapsed acute lymphoblastic leukaemia – Long-term results of trial ALL-REZ BFM P95/96. European Journal of Cancer, 49(6), 1346–1355.
pubmed: 23265714
doi: 10.1016/j.ejca.2012.11.010
Buratin, A., Paganin, M., Gaffo, E., Dal Molin, A., Roels, J., & Germano, G., et al. (2020). Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. Blood Advances, 4(23), 5902–5914.
pubmed: 33259601
pmcid: 7724907
doi: 10.1182/bloodadvances.2020002337
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012). Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One, 7(2), e30733.
pubmed: 22319583
pmcid: 3270023
doi: 10.1371/journal.pone.0030733
Dal Molin, A., Bresolin, S., Gaffo, E., Tretti, C., Boldrin, E., & Meyer, L. H., et al. (2019). CircRNAs are here to stay: a perspective on the mll recombinome. Frontiers in Genetics, 10, 88.
pubmed: 30815012
pmcid: 6382020
doi: 10.3389/fgene.2019.00088
Huang, W., Fang, K., Chen, T. Q., Zeng, Z. C., Sun, Y. M., & Han, C., et al. (2019). circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression. Journal of Hematology and Oncology, 12(1), 103.
pubmed: 31623653
pmcid: 6798510
doi: 10.1186/s13045-019-0800-z
Knoepfler, P. S. (2007). Myc goes global: new tricks for an old oncogene. Cancer Research, 67(11), 5061–5063.
pubmed: 17545579
doi: 10.1158/0008-5472.CAN-07-0426
Nguyen, L., Papenhausen, P., & Shao, H. (2017). The role of c-MYC in B-Cell Lymphomas: Diagnostic and molecular aspects. Genes, 8(4), 116.
pubmed: 28379189
pmcid: 5406863
doi: 10.3390/genes8040116
Dang, C. V., O’Donnell, K. A., Zeller, K. I., Nguyen, T., Osthus, R. C., & Li, F. (2006). The c-Myc target gene network. Seminars in Cancer Biology, 16(4), 253–264.
pubmed: 16904903
doi: 10.1016/j.semcancer.2006.07.014
Baluapuri, A., Wolf, E., & Eilers, M. (2020). Target gene-independent functions of MYC oncoproteins. Nature Review Molecular Cell Biology, 21(5), 255–267.
doi: 10.1038/s41580-020-0215-2
Ghetti, M., Vannini, I., Storlazzi, C. T., Martinelli, G., & Simonetti, G. (2020). Linear and circular PVT1 in hematological malignancies and immune response: two faces of the same coin. Molecular Cancer, 19(1), 69.
pubmed: 32228602
pmcid: 7104523
doi: 10.1186/s12943-020-01187-5
Palcau, A. C., Canu, V., Donzelli, S., Strano, S., Pulito, C., & Blandino, G. (2022). CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals. Molecular Cancer, 21(1), 33.
pubmed: 35090471
pmcid: 8796571
doi: 10.1186/s12943-022-01514-y
Zhou, X., Zhan, L., Huang, K., & Wang, X. (2020). The functions and clinical significance of circRNAs in hematological malignancies. Journal of Hematology Oncology, 13(1), 138.
pubmed: 33069241
pmcid: 7568356
doi: 10.1186/s13045-020-00976-1
Adhikary, J., Chakraborty, S., Dalal, S., Basu, S., Dey, A., & Ghosh, A. (2019). Circular PVT1: an oncogenic non-coding RNA with emerging clinical importance. Journal of Clinical Pathology, 72(8), 513–519.
pubmed: 31154423
doi: 10.1136/jclinpath-2019-205891
Ghafouri-Fard, S., Omrani, M. D., & Taheri, M. (2020). Long noncoding RNA PVT1: A highly dysregulated gene in malignancy. Journal of Cellular Physiology, 235(2), 818–835.
pubmed: 31297833
doi: 10.1002/jcp.29060
Chen, J., Li, Y., Zheng, Q., Bao, C., He, J., & Chen, B., et al. (2017). Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters, 388, 208–219.
pubmed: 27986464
doi: 10.1016/j.canlet.2016.12.006
Qin, S., Zhao, Y., Lim, G., Lin, H., Zhang, X., & Zhang, X. (2019). Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer progression. Biomedicine and Pharmacotherapy, 111, 244–250.
pubmed: 30590312
doi: 10.1016/j.biopha.2018.12.007
Hu, J., Han, Q., Gu, Y., Ma, J., McGrath, M., & Qiao, F., et al. (2018). Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia. Epigenomics, 10(6), 723–732.
pubmed: 29693417
doi: 10.2217/epi-2017-0142
Panda, A. C., Grammatikakis, I., Kim, K. M., De, S., Martindale, J. L., & Munk, R., et al. (2017). Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. Nucleic Acids Research, 45(7), 4021–4035.
pubmed: 27928058
doi: 10.1093/nar/gkw1201
Jia, Y., & Gu, W. (2021). Up-regulation of circPVT1 in T cell acute lymphoblastic leukemia promoted cell proliferation via miR-30e/DLL4 induced activating NOTCH signaling. Pathology Research and Practice, 224, 153536.
pubmed: 34237615
doi: 10.1016/j.prp.2021.153536
Jia, Y., Hu, H., & Gu, W. (2021). Regulation effects of circular RNA CircPVT1 and miR-125b on NF-κB Signal pathway in childhood all. Clinical Laboratory, 67(11), 2491.
Nasri Nasrabadi, P., Martin, D., Gharib, E., & Robichaud, G. A. (2022). The Pleiotropy of PAX5 gene products and function. International Journal of Molecular Sciences, 23(17), 10095.
pubmed: 36077495
pmcid: 9456430
doi: 10.3390/ijms231710095
Hannay, B., Dumas, P., Veilleux, V., LeBlanc, N., Robichaud, G. A. (2018). Discovery of novel non-coding products of the Pax-5 gene and their clinical significance in lymphoid cancers. The FASEB Journal. 32(S1):677−23.
Borson, N. D., Lacy, M. Q., & Wettstein, P. J. (2002). Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma. Blood, 100(13), 4629–4639.
pubmed: 12453881
doi: 10.1182/blood.V100.13.4629
King, J. K., Ung, N. M., Paing, M. H., Contreras, J. R., Alberti, M. O., & Fernando, T. R., et al. (2017). Regulation of marginal zone B-Cell differentiation by MicroRNA-146a. Frontiers in Immunology, 7, 670.
pubmed: 28138326
pmcid: 5237642
doi: 10.3389/fimmu.2016.00670
Liu, J., Kong, F., Lou, S., Yang, D., & Gu, L. (2018). Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b. Biochemical and Biophysical Research Communications, 504(4), 660–665.
pubmed: 30205959
doi: 10.1016/j.bbrc.2018.08.154
Zhang, X., Wang, S., Lin, G., & Wang, D. (2020). Down-regulation of circ-PTN suppresses cell proliferation, invasion and glycolysis in glioma by regulating miR-432-5p/RAB10 axis. Neurosciences Letters, 735, 135153.
doi: 10.1016/j.neulet.2020.135153
Zhu, X., Du, J., & Gu, Z. (2020). Circ-PVT1/miR-106a-5p/HK2 axis regulates cell growth, metastasis and glycolytic metabolism of oral squamous cell carcinoma. Molecular and Cellular Biochemistry, 474(1-2), 147–158.
pubmed: 32737775
doi: 10.1007/s11010-020-03840-5
Jiao, J., Zhang, T., Jiao, X., Huang, T., Zhao, L., & Ma, D., et al. (2020). hsa_circ_0000745 promotes cervical cancer by increasing cell proliferation, migration, and invasion. Journal of Cellular Physiology, 235(2), 1287–1295.
pubmed: 31256433
doi: 10.1002/jcp.29045
Huang, R., Zhang, Y., Han, B., Bai, Y., Zhou, R., & Gan, G., et al. (2017). Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Autophagy, 13(10), 1722–1741.
pubmed: 28786753
pmcid: 5640207
doi: 10.1080/15548627.2017.1356975
Liu, X., Zhou, C., Li, Y., Deng, Y., Lu, W., & Li, J. (2020). Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway. Gene, 751, 144726.
pubmed: 32360844
doi: 10.1016/j.gene.2020.144726
Feng, H., Li, F., & Tang, P. (2021). Circ_0000745 regulates NOTCH1-mediated cell proliferation and apoptosis in pediatric T-cell acute lymphoblastic leukemia through adsorbing miR-193b-3p. Hematology, 26(1), 885–895.
pubmed: 34753401
doi: 10.1080/16078454.2021.1997197
Zhu, Y., Ma, X., Zhang, H., Wu, Y., Kang, M., & Fang, Y., et al. (2021). Mechanism of circADD2 as ceRNA in Childhood Acute Lymphoblastic Leukemia. Frontiers in Cell and Developmental Biology, 9, 639910.
pubmed: 34055775
pmcid: 8155473
doi: 10.3389/fcell.2021.639910
Guo, S., Li, B., Chen, Y., Zou, D., Yang, S., & Zhang, Y., et al. (2020). Hsa_circ_0012152 and Hsa_circ_0001857 accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Frontiers in Oncology, 10, 1655.
pubmed: 32984037
pmcid: 7492294
doi: 10.3389/fonc.2020.01655
Legnini, I., Di Timoteo, G., Rossi, F., Morlando, M., Briganti, F., & Sthandier, O., et al. (2017). Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Molecular Cell, 66(1), 22–37.e9.
pubmed: 28344082
pmcid: 5387670
doi: 10.1016/j.molcel.2017.02.017
Tang, Y. L., Su, J. Y., Luo, J. S., Zhang, L. D., Zheng, L. M., & Liang, C., et al. (2023). Gene expression network and Circ_0008012 promote progression in MLL/AF4 positive acute lymphoblastic leukemia. Recent Patent on Anticancer Drug Discovery, 18(4), 538–548.
doi: 10.2174/1574892818666221207115016
Zhao, G., Chen, H., & Luo, J. (2023). CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in human B-prolymphocytic leukaemia cells via SLC7A11. Cellular and Molecular Biology, 69(12), 181–187.
pubmed: 38063095
doi: 10.14715/cmb/2023.69.12.29
Buratin, A., Borin, C., Tretti Parenzan, C., Dal Molin, A., Orsi, S., & Binatti, A., et al. (2023). CircFBXW7 in patients with T-cell ALL: depletion sustains MYC and NOTCH activation and leukemia cell viability. Experimental Hematology and Oncology, 12(1), 12.
pubmed: 36681829
pmcid: 9863195
doi: 10.1186/s40164-023-00374-6
Hou, Y., Sun, J., Huang, J., Yao, F., Chen, X., & Zhu, B., et al. (2021). Circular RNA circRNA_0000094 sponges microRNA-223-3p and up-regulate F-box and WD repeat domain containing 7 to restrain T cell acute lymphoblastic leukemia progression. Human Cell, 34(3), 977–989.
pubmed: 33677796
doi: 10.1007/s13577-021-00504-4
Hallek, M. (2017). Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment. Americal Journal of Hematology, 92(9), 946–965.
doi: 10.1002/ajh.24826
Nadeu, F., Delgado, J., Royo, C., Baumann, T., Stankovic, T., & Pinyol, M., et al. (2016). Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia. Blood, 127(17), 2122–2130.
pubmed: 26837699
pmcid: 4912011
doi: 10.1182/blood-2015-07-659144
Seiffert, M., Dietrich, S., Jethwa, A., Glimm, H., Lichter, P., & Zenz, T. (2012). Exploiting biological diversity and genomic aberrations in chronic lymphocytic leukemia. Leukemia and Lymphoma, 53(6), 1023–1031.
pubmed: 22023519
doi: 10.3109/10428194.2011.631638
Wu, Z., Sun, H., Wang, C., Liu, W., Liu, M., & Zhu, Y., et al. (2020). Mitochondrial genome-derived circRNA mc-COX2 functions as an oncogene in chronic lymphocytic leukemia. Molecular Therapy of Nucleic Acids, 20, 801–811.
pubmed: 32438315
doi: 10.1016/j.omtn.2020.04.017
Du, J., Jia, F., & Wang, L. (2022). Advances in the study of circRNAs in hematological malignancies. Frontiers of Oncology, 12, 900374.
doi: 10.3389/fonc.2022.900374
Mei, M., Wang, Y., Li, Z., & Zhang, M. (2019). Role of circular RNA in hematological malignancies. Oncology Lettera, 18(5), 4385–4392.
Wu, Z., Sun, H., Liu, W., Zhu, H., Fu, J., & Yang, C., et al. (2020). Circ-RPL15: a plasma circular RNA as novel oncogenic driver to promote progression of chronic lymphocytic leukemia. Leukemia, 34(3), 919–923.
pubmed: 31611623
doi: 10.1038/s41375-019-0594-6
Wang, M., Kluin, P. M., Rosati, S., Luinge, M., Daenen, S. M. G. J., & Visser, L. (2008). Raf-1 is over expressed in chronic lymphocytic leukemia and promotes cell survival by phosphorylation of ERK and BAD. Blood, 112(11), 3120.
doi: 10.1182/blood.V112.11.3120.3120
Xia, L., Wu, L., Bao, J., Li, Q., Chen, X., & Xia, H., et al. (2018). Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway. Biochemical and Biophysical Research Communications, 503(1), 385–390.
pubmed: 29902450
doi: 10.1016/j.bbrc.2018.06.045
Wu, W., Wu, Z., Xia, Y., Qin, S., Li, Y., & Wu, J., et al. (2019). Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis. Aging, 11(11), 3561–3573.
pubmed: 31152142
pmcid: 6594798
doi: 10.18632/aging.101997
Zhuang, Q., Shen, J., Chen, Z., Zhang, M., Fan, M., & Xue, D., et al. (2018). MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4. Cancer Biomarkers, 23(4), 515–525.
pubmed: 30452399
doi: 10.3233/CBM-181645
Zuo, X. L., Chen, Z. Q., Wang, J. F., Wang, J. G., Liang, L. H., & Cai, J. (2018). miR-337-3p suppresses the proliferation and invasion of hepatocellular carcinoma cells through targeting JAK2. American Journal of Cancer Research, 8(4), 662–674.
pubmed: 29736311
pmcid: 5934556
Demarez, C., Gérard, C., Cordi, S., Poncy, A., Achouri, Y., & Dauguet, N., et al. (2018). MicroRNA-337-3p controls hepatobiliary gene expression and transcriptional dynamics during hepatic cell differentiation. Hepatology, 67(1), 313–327.
pubmed: 28833283
doi: 10.1002/hep.29475
Liu, X., Wang, X., Li, J., Hu, S., Deng, Y., & Yin, H., et al. (2020). Identification of mecciRNAs and their roles in the mitochondrial entry of proteins. Science China Life Sciences, 63(10), 1429–1449.
pubmed: 32048164
doi: 10.1007/s11427-020-1631-9
Wu, Z., Zuo, X., Zhang, W., Li, Y., Gui, R., & Leng, J., et al. (2023). m6A-Modified circTET2 interacting with HNRNPC regulates fatty acid oxidation to promote the proliferation of chronic lymphocytic leukemia. Advanced Sciences, 10(34), e2304895.
Li, S., Chen, J., Fan, Y., Xu, X., Xiong, M., & Qi, Y., et al. (2022). circZNF91 promotes the malignant phenotype of chronic lymphocytic leukemia cells by targeting the miR-1283/WEE1 Axis. Biomedical Research International, 2022, 2855394.
Lu, R., Shao, Y., Ye, G., Xiao, B., & Guo, J. (2017). Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances. Tumour Biology, 39(6), 1010428317704175.
pubmed: 28656881
doi: 10.1177/1010428317704175
Zhang, Q., Wang, W., Zhou, Q., Chen, C., Yuan, W., & Liu, J., et al. (2020). Roles of circRNAs in the tumour microenvironment. Molecular Cancer, 19(1), 14.
pubmed: 31973726
pmcid: 6977266
doi: 10.1186/s12943-019-1125-9
Dal Molin, A., Tretti Parenzan, C., Gaffo, E., Borin, C., Boldrin, E., & Meyer, L. H., et al. (2023). Discovery of fusion circular RNAs in leukemia with KMT2A::AFF1 rearrangements by the new software CircFusion. Briefing in Bioinformatcis, 24(1), bbac589.
doi: 10.1093/bib/bbac589
Yang, X., Li, Y., Zhang, Y., & Liu, J. (2022). Circ_0000745 promotes acute lymphoblastic leukemia progression through mediating miR-494-3p/NET1 axis. Hematology, 27(1), 11–22.
pubmed: 34957935
doi: 10.1080/16078454.2021.2008590
Ling, Z., Fang, Z. G., Wu, J. Y., & Liu, J. J. (2021). The depletion of Circ-PRKDC enhances autophagy and apoptosis in T-cell acute lymphoblastic leukemia via microRNA-653-5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway. The Kaohsiung Journal Medical Sciences, 37(5), 392–401.
doi: 10.1002/kjm2.12352