The Voltage-Gated Calcium Channel α2δ Subunit in Neuropathic Pain.
Mechanism
Neuropathic pain
Pain signaling
Voltage-gated calcium ion channels
α2δ
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
13 Aug 2024
13 Aug 2024
Historique:
received:
17
06
2024
accepted:
06
08
2024
medline:
13
8
2024
pubmed:
13
8
2024
entrez:
13
8
2024
Statut:
aheadofprint
Résumé
Neuropathic pain (NP) is a chronic pain caused by injury or disease of the somatosensory nervous system, or it can be directly caused by disease. It often presents with clinical features like spontaneous pain, hyperalgesia, and dysesthesia. At present, voltage-gated calcium ion channels (VGCCs) are known to be closely related to the development of NP, especially the α2δ subunit. The α2δ subunit is a regulatory subunit of VGCCs. It exists mainly in the brain and peripheral nervous system, especially in nerve cells, and it plays a crucial part in regulating presynaptic and postsynaptic functions. Furthermore, the α2δ subunit influences neuronal excitation and pain signaling by promoting its expression and localization through binding to VGCC-related subunits. The α2δ subunit is widely used in the management of NP as a target of antiepileptic drugs gabapentin and pregabalin. Although drug therapy is one of the treatments for NP, its clinical application is limited due to the adverse reactions caused by drug therapy. Therefore, further research on the therapeutic target α2δ subunit is needed, and attempts are made to obtain an effective treatment for relieving NP without side effects. This review describes the current associated knowledge on the function of the α2δ subunit in perceiving and modulating NP.
Identifiants
pubmed: 39136907
doi: 10.1007/s12035-024-04424-w
pii: 10.1007/s12035-024-04424-w
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the National Natural Science Foundation of China
ID : 82372578
Organisme : the National Natural Science Foundation of China
ID : 82372578
Organisme : the National Natural Science Foundation of China
ID : 82372578
Organisme : the National Natural Science Foundation of China
ID : 82372578
Organisme : the National Natural Science Foundation of China
ID : 82372578
Organisme : Shanghai Youth Science and Technology Sail Project
ID : 23YF1444000
Organisme : Shanghai Youth Science and Technology Sail Project
ID : 23YF1444000
Organisme : Shanghai Youth Science and Technology Sail Project
ID : 23YF1444000
Organisme : Shanghai Youth Science and Technology Sail Project
ID : 23YF1444000
Organisme : Shanghai Youth Science and Technology Sail Project
ID : 23YF1444000
Organisme : Shanghai Municipal Education Commission - 2023 Shanghai College Young Teacher Training Funding Program
ID : A2-0202-24-0004-023
Organisme : Shanghai Municipal Education Commission - 2023 Shanghai College Young Teacher Training Funding Program
ID : A2-0202-24-0004-023
Organisme : Shanghai Municipal Education Commission - 2023 Shanghai College Young Teacher Training Funding Program
ID : A2-0202-24-0004-023
Organisme : Shanghai Municipal Education Commission - 2023 Shanghai College Young Teacher Training Funding Program
ID : A2-0202-24-0004-023
Organisme : Shanghai Municipal Education Commission - 2023 Shanghai College Young Teacher Training Funding Program
ID : A2-0202-24-0004-023
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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