PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression.
ErbB Receptors
/ metabolism
Copper
/ metabolism
Humans
Cyclic AMP Response Element-Binding Protein
/ metabolism
Signal Transduction
Copper Transporter 1
/ metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 2
/ metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1
/ metabolism
Transcription, Genetic
/ drug effects
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 Aug 2024
13 Aug 2024
Historique:
received:
30
08
2023
accepted:
10
07
2024
medline:
14
8
2024
pubmed:
14
8
2024
entrez:
13
8
2024
Statut:
epublish
Résumé
Fluxes in human copper levels recently garnered attention for roles in cellular signaling, including affecting levels of the signaling molecule cyclic adenosine monophosphate. We herein apply an unbiased temporal evaluation of the signaling and whole genome transcriptional activities modulated by copper level fluctuations to identify potential copper sensor proteins responsible for driving these activities. We find that fluctuations in physiologically relevant copper levels modulate EGFR signal transduction and activation of the transcription factor CREB. Both intracellular and extracellular assays support Cu
Identifiants
pubmed: 39138174
doi: 10.1038/s41467-024-50524-5
pii: 10.1038/s41467-024-50524-5
doi:
Substances chimiques
ErbB Receptors
EC 2.7.10.1
Copper
789U1901C5
Cyclic AMP Response Element-Binding Protein
0
EGFR protein, human
EC 2.7.10.1
CREB1 protein, human
0
Copper Transporter 1
0
Protein Tyrosine Phosphatase, Non-Receptor Type 2
EC 3.1.3.48
PTPN2 protein, human
EC 3.1.3.48
SLC31A1 protein, human
0
Protein Tyrosine Phosphatase, Non-Receptor Type 1
EC 3.1.3.48
PTPN1 protein, human
EC 3.1.3.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6947Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS)
ID : R01ES030546
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS)
ID : K99ES034084
Organisme : U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
ID : HG006827
Organisme : Breast Cancer Research Foundation (BCRF)
ID : FP049439
Informations de copyright
© 2024. The Author(s).
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