Neuropeptide alpha-Melanocyte stimulating hormone preserves corneal endothelial morphology in a murine model of Fuchs dystrophy.

Animals alpha-MSH / pharmacology Mice Disease Models, Animal Endothelium, Corneal / drug effects Humans Fuchs' Endothelial Dystrophy / pathology DNA Damage / drug effects Oxidative Stress / drug effects Ultraviolet Rays / adverse effects Cell Line Hydrogen Peroxide / pharmacology
Corneal endothelium DNA damage Fuchs endothelial corneal dystrophy alpha-Melanocyte stimulating hormone (α-MSH)

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
14 Aug 2024
Historique:
received: 29 04 2024
accepted: 05 08 2024
medline: 14 8 2024
pubmed: 14 8 2024
entrez: 13 8 2024
Statut: epublish

Résumé

Fuchs endothelial corneal dystrophy is a heterogenous disease with multifactorial etiology, and genetic, epigenetic, and exogenous factors contributing to its pathogenesis. DNA damage plays a significant role, with ultraviolet-A (UV-A) emerging as a key contributing factor. We investigate the potential application of neuropeptide α-melanocyte stimulating hormone (α-MSH) in mitigating oxidative stress induced endothelial damage. First, we examined the effects of α-MSH on a cultured human corneal endothelial cell line (HCEnC-21T) exposed to hydrogen peroxide (H

Identifiants

DOI: 10.1038/s41598-024-69416-1 PMID: 39138334
pubmed: 39138334
doi: 10.1038/s41598-024-69416-1
pii: 10.1038/s41598-024-69416-1
doi:

Substances chimiques

alpha-MSH 581-05-5
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

18842

Subventions

Organisme : NEI NIH HHS
ID : R21EY032695
Pays : United States

Informations de copyright

© 2024. The Author(s).

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Auteurs

Francesca Kahale (F)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Hamid Alemi (H)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Amirreza Naderi (A)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Neha Deshpande (N)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Seokjoo Lee (S)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Shudan Wang (S)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Rohan Bir Singh (RB)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Thomas Dohlman (T)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Jia Yin (J)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Ula Jurkunas (U)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA.

Reza Dana (R)

Laboratory of Corneal Immunology, Transplantation and Regeneration, Department of Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA. Reza_Dana@meei.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones mélanotropes › Hormone mélanotrope alpha › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium de la cornée › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies héréditaires de l'oeil › Dystrophies héréditaires de la cornée › Dystrophie endothéliale de Fuchs › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons ultraviolets › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Neuropeptide alpha-Melanocyte stimulating...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Neuropeptide alpha-Melanocyte stimulating...