Influence of comorbidities on outcome in 1102 patients with an allogeneic hematopoietic stem cell transplantation.


Journal

Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459

Informations de publication

Date de publication:
13 Aug 2024
Historique:
received: 28 11 2023
accepted: 06 08 2024
revised: 29 07 2024
medline: 14 8 2024
pubmed: 14 8 2024
entrez: 13 8 2024
Statut: aheadofprint

Résumé

The hematopoietic comorbidity risk index (HCT-CI) is a pre-transplant risk assessment tool used to qualify comorbidities to predict non-relapse mortality (NRM) of patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). HSCT procedures continue to improve. Therefore, the predictive value of HCT-CI needs to be re-evaluated. Our study is a retrospective analysis of pre-existing comorbidities assessing the relevance of the HCT-CI on the outcome of consecutive patients (n = 1102) undergoing allo-HSCT from 2006-2021. HCT-CI was classified as low (HCT-CI 0), intermediate (HCT-CI 1-2) and high-risk (HCT-CI ≥ 3). At 10 years, NRM for low, intermediate, and high-risk HCT-CI group was 21.0%, 26.0%, and 25.8% (p = 0.04). NRM difference was significant between low to intermediate (p < 0.001), but not between intermediate to high-risk HCT-CI (p = 0.22). Overall survival (OS) at 10 years differed significantly with 49.9%, 39.8%, and 31.1%, respectively (p < 0.001). In multivariate analysis of HCT-CI organ subgroups, cardiac disease was most strongly associated with NRM (HR = 1.73, p = 0.02) and OS (HR = 1.77, p < 0.001). All other individual organ comorbidities influenced NRM to a lesser extent. Further, donor (HR = 2.20, p < 0.001 for unrelated and HR = 2.17, p = 0.004 for mismatched related donor), disease status (HR = 1.41, p = 0.03 for advanced disease) and previous HSCT (HR = 1.55, p = 0.009) were associated with NRM. Improvement in transplant techniques and supportive care may have improved outcome with respect to comorbidities.

Identifiants

pubmed: 39138337
doi: 10.1038/s41409-024-02395-z
pii: 10.1038/s41409-024-02395-z
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Marie Janscak (M)

Division of Hematology, University Hospital Basel, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Anne Stelmes (A)

Division of Hematology, University Hospital Basel, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Jana van den Berg (J)

Division of Hematology, University Hospital Basel, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Dominik Heim (D)

Division of Hematology, University Hospital Basel, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Joerg Halter (J)

Division of Hematology, University Hospital Basel, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Beatrice Drexler (B)

Division of Hematology, University Hospital Basel, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Christian Arranto (C)

University of Basel, Basel, Switzerland.

Jakob Passweg (J)

Division of Hematology, University Hospital Basel, Basel, Switzerland.
University of Basel, Basel, Switzerland.

Michael Medinger (M)

Division of Hematology, University Hospital Basel, Basel, Switzerland. michael.medinger@usb.ch.
University of Basel, Basel, Switzerland. michael.medinger@usb.ch.

Classifications MeSH