Intervention portfolios analysis of Plasmodium vivax control in central China.
Plasmodium vivax
Intervention strategy
Portfolios analysis
The People’s Republic of China
Transmission model
Journal
Malaria journal
ISSN: 1475-2875
Titre abrégé: Malar J
Pays: England
ID NLM: 101139802
Informations de publication
Date de publication:
13 Aug 2024
13 Aug 2024
Historique:
received:
27
03
2024
accepted:
30
07
2024
medline:
14
8
2024
pubmed:
14
8
2024
entrez:
13
8
2024
Statut:
epublish
Résumé
The effects of a diverse spectrum of malaria interventions were evaluated through a deterministic Plasmodium vivax transmission model. This approach aimed to provide theoretical evidence of the performance of these interventions once implemented for achieving malaria elimination. An integrated intervention portfolio, including mass drug administration, insecticide treatment, and untreated bed nets, was analyzed through modeling. Additionally, data-driven calibration was implemented to infer coverages that effectively reproduced historical malaria patterns in China from 1971 to 1983. MDA utilizing primaquine emerged as the most effective single intervention, achieving a 70% reduction in malaria incidence when implemented at full coverage. Furthermore, a strategic combination of MDA with primaquine, chloroquine, untreated bed nets, and seasonal insecticide treatments effectively eradicated malaria, attaining elimination at a coverage level of 70%. It was conclusively demonstrated that an integrated approach combining MDA and vector control measures is essential for the successful elimination of malaria. High coverage of mass drug administration with primaquine and chloroquine before transmission was the key driver of the malaria decline in China from 1971 to 1983. The best-fit intervention coverage combinations derived from calibration are provided as a reference for malaria control in other countries.
Sections du résumé
BACKGROUND
BACKGROUND
The effects of a diverse spectrum of malaria interventions were evaluated through a deterministic Plasmodium vivax transmission model. This approach aimed to provide theoretical evidence of the performance of these interventions once implemented for achieving malaria elimination.
METHODS
METHODS
An integrated intervention portfolio, including mass drug administration, insecticide treatment, and untreated bed nets, was analyzed through modeling. Additionally, data-driven calibration was implemented to infer coverages that effectively reproduced historical malaria patterns in China from 1971 to 1983.
RESULTS
RESULTS
MDA utilizing primaquine emerged as the most effective single intervention, achieving a 70% reduction in malaria incidence when implemented at full coverage. Furthermore, a strategic combination of MDA with primaquine, chloroquine, untreated bed nets, and seasonal insecticide treatments effectively eradicated malaria, attaining elimination at a coverage level of 70%. It was conclusively demonstrated that an integrated approach combining MDA and vector control measures is essential for the successful elimination of malaria.
CONCLUSION
CONCLUSIONS
High coverage of mass drug administration with primaquine and chloroquine before transmission was the key driver of the malaria decline in China from 1971 to 1983. The best-fit intervention coverage combinations derived from calibration are provided as a reference for malaria control in other countries.
Identifiants
pubmed: 39138510
doi: 10.1186/s12936-024-05063-1
pii: 10.1186/s12936-024-05063-1
doi:
Substances chimiques
Antimalarials
0
Primaquine
MVR3634GX1
Chloroquine
886U3H6UFF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
242Subventions
Organisme : Hainan Nature Science Foundation
ID : 122RC679
Organisme : Hainan Nature Science Foundation
ID : 821CXTD440
Organisme : Scientific Research Foundation of Hainan Medical University
ID : 2020030
Organisme : National Natural Science Foundation of China
ID : 82260655
Informations de copyright
© 2024. The Author(s).
Références
Carter R, Mendis KN. Evolutionary and historical aspects of the burden of malaria. Clin Microbiol Rev. 2002;15:564–94.
doi: 10.1128/CMR.15.4.564-594.2002
pubmed: 12364370
pmcid: 126857
Gimnig JE, Ombok M, Bayoh N, Mathias D, Ochomo E, Jany W, et al. Efficacy of extended release formulations of Natular™ (spinosad) against larvae and adults of Anopheles mosquitoes in western Kenya. Malar J. 2020;19:436.
doi: 10.1186/s12936-020-03507-y
pubmed: 33243237
pmcid: 7691113
WHO. World Malaria Report 2021. Geneva: World Health Organization; 2021.
WHO. From 30 million cases to zero: China is certified malaria-free by WHO. Geneva: World Health Organization; 2021.
Shang L. Malaria epidemic and control in Henan Province. Zhengzhou: Central China Publishing; 2011.
Ministry of Health. National malaria elimination action plan (2010–2020). Beijing: Ministry of Health of China; 2010.
Tang LH, Qian HL, Xu SH. Malaria and its control in the People’s Republic of China. Southeast Asian J Trop Med Public Health. 1991;22:467–76.
pubmed: 1820632
Xu J-W, Lee R, Li X-H, Liu H. Transition of radical, preventive and presumptive treatment regimens for malaria in China: a systematic review. Malar J. 2021;20:10.
doi: 10.1186/s12936-020-03535-8
pubmed: 33407512
pmcid: 7788889
Yip K. Antimalarial work in China: a historical perspective. Parassitologia. 1998;40:29–38.
pubmed: 9653729
Hsiang MS, Hwang J, Tao AR, et al. Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China. Malar J. 2013;12(1):1–14.
doi: 10.1186/1475-2875-12-383
Kassam R, Collins JB, Liow E, Rasool N. Narrative review of current context of malaria and management strategies in Uganda (part I). Acta Trop. 2015;152:252–68.
doi: 10.1016/j.actatropica.2015.07.028
pubmed: 26257070
Edossa DG, Wedajo AG, Koya KP. Modeling the dynamics of endemic malaria transmission with the effects of control measure. Am J Appl Math. 2020. https://doi.org/10.11648/j.ajam.20200803.17 .
doi: 10.11648/j.ajam.20200803.17
Beretta E, Capasso V, Garao DG. A mathematical model for malaria transmission with asymptomatic carriers and two age groups in the human population. Mathl Biosci. 2018;300:87–101.
doi: 10.1016/j.mbs.2018.03.024
White MT, Shirreff G, Karl S, Ghani AC, Mueller I. Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria. Proc Biol Sci. 2016;283:20160048.
pubmed: 27030414
pmcid: 4822465
R.C. Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2022.
Yang GJ, Liu Y, Shang L-Y, Zhang X-N, Zhou XN, Penny MA, et al. From Plasmodium vivax outbreak to elimination: lessons learnt from a retrospective analysis of data from Guantang. Malar J. 2020;19:427.
doi: 10.1186/s12936-020-03501-4
pubmed: 33228679
pmcid: 7684948
Yadav CP, Gupta S, Bharti PK, Rahi M, Faizi N, Sharma A. India may need an additional metric to assess the endemicity of malaria in low surveillance districts. PLoS Glob Public Health. 2022;2: e0000326.
doi: 10.1371/journal.pgph.0000326
pubmed: 36962502
pmcid: 10021988
Garrett-Jones C. The human blood index of malaria vectors in relation to epidemiological assessment. Bull World Health Organ. 1964;30:241–61.
pubmed: 14153413
pmcid: 2554803
Gething PW, Van Boeckel TP, Smith DL, Guerra CA, Patil AP, Snow RW, et al. Modelling the global constraints of temperature on transmission of Plasmodium falciparum and P. vivax. Parasit Vectors. 2011;4:92.
doi: 10.1186/1756-3305-4-92
pubmed: 21615906
pmcid: 3115897
Poirot E, Skarbinski J, Sinclair D, Kachur SP, Slutsker L, Hwang J. Mass drug administration for malaria. Cochrane Database Syst Rev. 2013;2013:8846.
Zou H. Observation on mass mosquito control effect of Zou County Central commune. Shandong Med J. 1974;4:17–22 (in Chinese).
Li Q, Yang F, Liu R, Luo L, Yang Y, Zhang L, et al. Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency at the China–Myanmar border. PLoS ONE. 2015;10: e0134593.
doi: 10.1371/journal.pone.0134593
pubmed: 26226515
pmcid: 4520570
Taylor WRJ, Thriemer K, von Seidlein L, Yuentrakul P, Assawariyathioat T, Assefa A, et al. Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial. Lancet. 2019;394:929–38.
doi: 10.1016/S0140-6736(19)31285-1
pubmed: 31327563
pmcid: 6753019
Editorial. The patriotic health campaign and its promotion on National health in the new era. Yi Xue Yu Zhe Xue. 2018;39:34–7 (in Chinese).
Feng X, Feng J, Zhang L, Tu H, Xia Z. Vector control in China, from malaria endemic to elimination and challenges ahead. Infect Dis Poverty. 2022;11:54.
doi: 10.1186/s40249-022-00971-3
pubmed: 35562786
pmcid: 9102289
Bhatt S, Weiss DJ, Cameron E, Bisanzio D, Mappin B, Dalrymple U, et al. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature. 2015;526:207–11.
doi: 10.1038/nature15535
pubmed: 26375008
pmcid: 4820050
Blackburn BG, Eigege A, Gotau H, Gerlong G, Miri E, Hawley WA, et al. Successful integration of insecticide-treated bed net distribution with mass drug administration in Central Nigeria. Am J Trop Med Hyg. 2006;75:650–5.
doi: 10.4269/ajtmh.2006.75.650
pubmed: 17038688
Gitaka J, Chan C, Kongere J, Kagaya W, Kaneko A. Mass drug administration (MDA) integrated malaria elimination in a hypo-endemic island in lake Victoria, Kenya. BMJ Glob Health. 2017;2:A14.
doi: 10.1136/bmjgh-2016-000260.33
Yukich JO, Scott CA, Silumbe K, Larson BA, Bennett A, Finn T, et al. Cost-effectiveness of focal mass drug administration and mass drug administration with dihydroartemisinin–piperaquine for malaria prevention in Southern Province, Zambia: results of a community-randomized controlled trial. Am J Trop Med Hyg. 2020;103:46–53.
doi: 10.4269/ajtmh.19-0661
pubmed: 32618249
pmcid: 7416981
Griffin JT, Hollingsworth TD, Okell LC, Churcher TS, White MT, Hinsley W, et al. Reducing Plasmodium falciparum malaria transmission in africa: a model-based evaluation of intervention strategies. PLoS Med. 2010;7: e1000324.
doi: 10.1371/journal.pmed.1000324
pubmed: 20711482
pmcid: 2919425
Kiware SS, Chitnis N, Tatarsky A, Wu SL, Castellanos HMS, Gosling R, et al. Attacking the mosquito on multiple fronts: insights from the vector control optimization model (VCOM) for malaria elimination. PLoS ONE. 2017;12: e0187680.
doi: 10.1371/journal.pone.0187680
pubmed: 29194440
pmcid: 5711017
Roy M, Bouma M, Dhiman RC, Pascual M. Predictability of epidemic malaria under non-stationary conditions with process-based models combining epidemiological updates and climate variability. Malar J. 2015;14:419.
doi: 10.1186/s12936-015-0937-3
pubmed: 26502881
pmcid: 4623260