Laterality, heterotaxy, and isolated congenital heart defects : The genetic basis of the segmental nature of the heart.
Congenital heart disease
Heterotaxy
Laterality defects
Laterality genes
Nodal
Journal
Genome medicine
ISSN: 1756-994X
Titre abrégé: Genome Med
Pays: England
ID NLM: 101475844
Informations de publication
Date de publication:
13 Aug 2024
13 Aug 2024
Historique:
received:
24
07
2024
accepted:
08
08
2024
medline:
14
8
2024
pubmed:
14
8
2024
entrez:
13
8
2024
Statut:
epublish
Résumé
To date, the role of NODAL in normal and abnormal L-R asymmetry has been well established. In a recent paper, mutations of this gene have been reported in heterotaxy but also in transposition with D- or L-ventricular loop. The effects of NODAL and other laterality genes can be recognized separately in all three cardiac segments: for topology and septation of the atria, for ventricular looping, and for spiralization and alignment of the great arteries.
Identifiants
pubmed: 39138574
doi: 10.1186/s13073-024-01375-8
pii: 10.1186/s13073-024-01375-8
doi:
Substances chimiques
Nodal Protein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100Informations de copyright
© 2024. The Author(s).
Références
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