State of the art of sepsis care for the emergency medicine clinician.

Sepsis impacts 1.7 million Americans annually. It is a life-threatening disruption of organ function because of the body's host response to infection. Sepsis remains a condition frequently encountered in emergency departments (ED) with an estimated 850,000 annual visits affected by sepsis each year in the United States. The pillars of managing sepsis remain timely identification, initiation of antimicrobials while aiming for source control and resuscitation with a goal of restoring tissue perfusion. The focus herein is current evidence and best practice recommendations for state-of-the-art sepsis care that begins in the ED.

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© 2024 The Author(s). Journal of the American College of Emergency Physicians Open published by Wiley Periodicals LLC on behalf of American College of Emergency Physicians.

Déclaration de conflit d'intérêts

N. Jayaprakash received Honorarium for CHEST 2023 (travel), Site PI for grants to institution: Abbott laboratories sponsored LANER‐HF trial; NIH sponsored AIMS trial; Biocogniv sponsored Sepsis AI marker study. N. Sarani worked for Beckman Coulter Diagnostics: Site PI: Linking Novel Diagnostics with Data‐Driven Clinical Decision Support Prenosis: Site PI: Early stratification of septic patients, consulting on clinical utility of monocyte distribution width in the acute care setting.