The informatics of ADNI.
Alzheimer's Disease Neuroimaging Initiative
Alzheimer's disease
biomarkers
data sharing
informatics
open data
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
14 Aug 2024
14 Aug 2024
Historique:
revised:
31
05
2024
received:
02
05
2024
accepted:
03
06
2024
medline:
14
8
2024
pubmed:
14
8
2024
entrez:
14
8
2024
Statut:
aheadofprint
Résumé
The Alzheimer's Disease Neuroimaging Initiative (ADNI) has revolutionized the landscape of Alzheimer's research through its Informatics Core, which has facilitated unprecedented data standardization and sharing. Over 20 years, ADNI established a robust informatics framework, enabling the validation of biomarkers and supporting global research efforts. The Informatics Core, centered at the Laboratory of Neuro Imaging (LONI), provides a comprehensive data hub that ensures data quality, accessibility, and security, fostering over 5600 publications and significant scientific advancements. By embracing open data sharing principles, ADNI set a gold standard in data transparency, allowing over 26,000 investigators from 169 countries to access and download a wealth of multimodal data. This collaborative approach not only accelerated biomarker discovery and drug development and advanced our understanding of Alzheimer's disease but also has served as a model for other research initiatives, demonstrating the transformative potential of carefully designed informatics models and shared data in driving global scientific progress. HIGHLIGHTS: Accelerating biomarker discovery and drug development for Alzheimer's disease. Alzheimer's Disease Neuroimaging Initiative's (ADNI's) open data sharing drives scientific progress. Data exploration and coupled analytics to data archives.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
Pays : United States
Organisme : NIH HHS
ID : U19AG024904
Pays : United States
Organisme : Northern California Institute for Research and Education
Organisme : NIBIB NIH HHS
Pays : United States
Organisme : CIHR
Pays : Canada
Organisme : Foundation for the National Institutes of Health
Organisme : AbbVie, Alzheimer's Association
Organisme : Alzheimer's Drug Discovery Foundation
Organisme : Araclon Biotech
Organisme : BioClinica, Inc.
Organisme : Biogen
Organisme : Bristol-Myers Squibb Company
Organisme : CereSpir, Inc.
Organisme : Cogstate
Organisme : Eisai Inc.
Organisme : Elan Pharmaceuticals, Inc.
Organisme : Eli Lilly and Company
Organisme : EuroImmun
Organisme : F. Hoffmann-La Roche Ltd
Organisme : Genentech, Inc.
Organisme : Fujirebio
Organisme : GE Healthcare
Organisme : IXICO Ltd.
Organisme : Janssen Alzheimer Immunotherapy Research & Development, LLC.
Organisme : Johnson & Johnson Pharmaceutical Research & Development LLC.
Organisme : Lumosity
Organisme : Lundbeck
Organisme : Merck & Co., Inc.
Organisme : Meso Scale Diagnostics, LLC.
Organisme : NeuroRx Research
Organisme : Neurotrack Technologies
Organisme : Novartis Pharmaceuticals Corporation
Organisme : Pfizer Inc.
Organisme : Piramal Imaging
Organisme : Servier
Organisme : Takeda Pharmaceutical Company
Organisme : Transition Therapeutics
Informations de copyright
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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