Schwann cell-secreted PGE

PGE2 Schwann cells excitability glial cells neural development neuron-glia interactions prostaglandin sensory behavior sensory neuron voltage-gated sodium channels

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
06 Aug 2024
Historique:
received: 27 03 2023
revised: 18 04 2024
accepted: 21 06 2024
medline: 15 8 2024
pubmed: 15 8 2024
entrez: 14 8 2024
Statut: aheadofprint

Résumé

Electrical excitability-the ability to fire and propagate action potentials-is a signature feature of neurons. How neurons become excitable during development and whether excitability is an intrinsic property of neurons remain unclear. Here, we demonstrate that Schwann cells, the most abundant glia in the peripheral nervous system, promote somatosensory neuron excitability during development. We find that Schwann cells secrete prostaglandin E

Identifiants

DOI: 10.1016/j.cell.2024.07.033 PMID: 39142281
pubmed: 39142281
pii: S0092-8674(24)00827-4
doi: 10.1016/j.cell.2024.07.033
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests J.D.B. is a cofounder and holds equity shares in SiteOne Therapeutics, Inc., a start-up company developing subtype-selective modulators of Na(V)s.

Auteurs

Husniye Kantarci (H)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Pablo D Elvira (PD)

Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

Arun P Thottumkara (AP)

Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

Emma M O'Connell (EM)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Manasi Iyer (M)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Lauren J Donovan (LJ)

Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Micaela Quinn Dugan (MQ)

Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Nicholas Ambiel (N)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Alejandro Granados (A)

Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

Hong Zeng (H)

Transgenic, Knockout and Tumor model Center (TKTC), Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Nay L Saw (NL)

Behavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA 94305, USA.

Amanda Brosius Lutz (A)

Department of Obstetrics and Gynecology, University Hospital, Bern, Switzerland.

Steven A Sloan (SA)

Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Erin E Gray (EE)

Department of Chemistry, Stanford University, Stanford, CA 94305, USA.

Khanh V Tran (KV)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Aditi Vichare (A)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Ashley K Yeh (AK)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Alexandra E Münch (AE)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Max Huber (M)

Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

Aditi Agrawal (A)

Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

Maurizio Morri (M)

Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

Haining Zhong (H)

Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.

Mehrdad Shamloo (M)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Behavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA 94305, USA.

Thomas Anthony Anderson (TA)

Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Vivianne L Tawfik (VL)

Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

J Du Bois (J)

Department of Chemistry, Stanford University, Stanford, CA 94305, USA. Electronic address: jdubois@stanford.edu.

J Bradley Zuchero (JB)

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: zuchero@stanford.edu.

Classifications MeSH