The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against

Plasmodium falciparum SQ109 antimalarial multistage transmission-blocking

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
14 Aug 2024
Historique:
medline: 15 8 2024
pubmed: 15 8 2024
entrez: 14 8 2024
Statut: aheadofprint

Résumé

Toward repositioning the antitubercular clinical candidate SQ109 as an antimalarial, analogs were investigated for structure-activity relationships for activity against asexual blood stages of the human malaria parasite

Identifiants

DOI: 10.1021/acsinfecdis.4c00461 PMID: 39143042
pubmed: 39143042
doi: 10.1021/acsinfecdis.4c00461
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Savannah J Watson (SJ)

Mariëtte E van der Watt (ME)

Anjo Theron (A)

Next Generation Health, Council for Scientific and Industrial Research, Pretoria 0001, South Africa.

Janette Reader (J)

Sizwe Tshabalala (S)

Erica Erlank (E)

Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Services, Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Johannesburg 2000, South Africa.

Lizette L Koekemoer (LL)

Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Services, Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Johannesburg 2000, South Africa.

Mariska Naude (M)

Marianna Stampolaki (M)

Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis-Zografou, 15771 Athens, Greece.

Feyisola Adewole (F)

Department of Biological, Physical and Health Sciences, College of Science, Health & Pharmacy, Roosevelt University, 425 South Wabash Avenue, Chicago, Illinois 60605, United States.

Katie Sadowska (K)

Department of Biological, Physical and Health Sciences, College of Science, Health & Pharmacy, Roosevelt University, 425 South Wabash Avenue, Chicago, Illinois 60605, United States.

Pilar Pérez-Lozano (P)

Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona 08028, Spain.
ORCID: 0000-0001-6899-066X

Andreea L Turcu (AL)

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l'Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Barcelona E-08028, Spain.

Santiago Vázquez (S)

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l'Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Barcelona E-08028, Spain.
ORCID: 0000-0002-9296-6026

Jihee Ko (J)

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
ORCID: 0000-0002-7970-1509

Ben Mazurek (B)

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
ORCID: 0000-0002-8555-4963

Davinder Singh (D)

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

Satish R Malwal (SR)

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
ORCID: 0000-0001-7606-1932

Mathew Njoroge (M)

Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Capetown 7701, South Africa.

Kelly Chibale (K)

Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Capetown 7701, South Africa.
South African Medical Research Council Drug Discovery and Development Centre, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Capetown 7701, South Africa.
ORCID: 0000-0002-1327-4727

Oluseye K Onajole (OK)

Department of Biological, Physical and Health Sciences, College of Science, Health & Pharmacy, Roosevelt University, 425 South Wabash Avenue, Chicago, Illinois 60605, United States.

Antonios Kolocouris (A)

Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis-Zografou, 15771 Athens, Greece.
ORCID: 0000-0001-6110-1903

Eric Oldfield (E)

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
ORCID: 0000-0002-0996-7352

Lyn-Marié Birkholtz (LM)

ORCID: 0000-0001-5888-2905

Classifications MeSH