Assessment of the Diuretic Effect of the Leaves of

Background

The diuretic activity of the

Objective

The objective of this study was to assess the diuretic activity of the aqueous and 80% methanol extracts derived from the leaves of

Methods

For the extraction process, the maceration technique was employed to obtain the aqueous and 80% methanol extracts from the

Results

Both the aqueous and 80% methanol extracts of Cucumis dipsaceus leaves demonstrated a significant increase in urinary output at doses of 200mg/kg body weight (p<0.01) and 400mg/kg body weight (p<0.001). When comparing the urinary electrolyte excretion with the negative control group, the groups treated with the 400mg/kg body weight dose of the aqueous extract showed significant differences in the urinary excretion of sodium (p<0.05), chloride (p<0.01), and K+ (p<0.01). Similarly, the urinary excretion of K+ and Cl- also exhibited significant differences at moderate doses (K+: p<0.01, Cl-: p<0.05) and the highest doses (both: p<0.01) of the 80% methanol extract. Furthermore, the highest doses of both the aqueous (p<0.01) and 80% methanol (p<0.01) extracts demonstrated significant differences in saluretic effect.

Conclusion

Both crude extracts of

Informations de copyright

© 2024 Asefa and Nedi.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest in this work.