A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice.

Animals Vacuolar Proton-Translocating ATPases / antagonists & inhibitors Single-Domain Antibodies / pharmacology Female Lung Neoplasms / secondary Mice Cell Line, Tumor Breast Neoplasms / pathology Mice, Inbred BALB C Humans Neoplasm Invasiveness
breast cancer invasion tumor growth tumor metastasis vacuolar ATPase

Journal

Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965

Informations de publication

Date de publication:
14 Aug 2024
Historique:
medline: 15 8 2024
pubmed: 15 8 2024
entrez: 15 8 2024
Statut: epublish

Résumé

The vacuolar H

Identifiants

DOI: 10.18632/oncotarget.28638 PMID: 39145534
pubmed: 39145534
pii: 28638
doi: 10.18632/oncotarget.28638
doi:

Substances chimiques

Vacuolar Proton-Translocating ATPases EC 3.6.1.-
Single-Domain Antibodies 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

575-587

Auteurs

Zhen Li (Z)

Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Department of Cancer Immunology and Virology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

Mohammed A Alshagawi (MA)

Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Department of Pharmacology, University of Minnesota School of Medicine, MN 55455, USA.

Rebecca A Oot (RA)

Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Mariam K Alamoudi (MK)

Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.

Kevin Su (K)

Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Korro Bio, Cambridge, MA 02139, USA.

Wenhui Li (W)

Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.

Michael P Collins (MP)

Program in Cellular, Molecular and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Foghorn Therapeutics, Cambridge, MA 02139, USA.

Stephan Wilkens (S)

Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Michael Forgac (M)

Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.
Program in Cellular, Molecular and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A nanobody against the V-ATPase c subunit...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Pompes à protons › Proton-Translocating ATPases › Vacuolar Proton-Translocating ATPases › A nanobody against the V-ATPase c subunit...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Fragments d'immunoglobuline › Fragments Fab d'immunoglobuline › Anticorps à domaine unique › A nanobody against the V-ATPase c subunit...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › A nanobody against the V-ATPase c subunit...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A nanobody against the V-ATPase c subunit...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › A nanobody against the V-ATPase c subunit...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › A nanobody against the V-ATPase c subunit...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › A nanobody against the V-ATPase c subunit...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A nanobody against the V-ATPase c subunit...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Invasion tumorale › A nanobody against the V-ATPase c subunit...