Airway derived emphysema-specific alveolar type II cells exhibit impaired regenerative potential in COPD.

Journal

The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460

Informations de publication

Date de publication:
15 Aug 2024
Historique:
received: 28 11 2023
accepted: 25 07 2024
medline: 16 8 2024
pubmed: 16 8 2024
entrez: 15 8 2024
Statut: aheadofprint

Résumé

Emphysema, the progressive destruction of gas exchange surfaces in the lungs, is a hallmark of chronic obstructive pulmonary disease (COPD) that is presently incurable. This therapeutic gap is largely due to a poor understanding of potential drivers of impaired tissue regeneration, such as abnormal lung epithelial progenitor cells, including alveolar type II (ATII) and airway club cells. We discovered an emphysema-specific sub-population of ATII cells located in enlarged distal alveolar sacs, termed asATII cells. Single cell RNA-seq and

Identifiants

DOI: 10.1183/13993003.02071-2023 PMID: 39147413
pubmed: 39147413
pii: 13993003.02071-2023
doi: 10.1183/13993003.02071-2023
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright ©The authors 2024. For reproduction rights and permissions contact permissions@ersnet.org.

Auteurs

Yan Hu (Y)

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States.
ORCID: 0000-0003-0586-6527

Qianjiang Hu (Q)

Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
ORCID: 0000-0003-1069-3181

Meshal Ansari (M)

Comprehensive Pneumology Center (CPC)/Institute of Lung Health and Immunity (LHI), Helmholtz Munich; Member of the German Center for Lung Research (DZL), Munich, Germany.

Kent Riemondy (K)

RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, CO, United States.

Ricardo Pineda (R)

Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.
ORCID: 0000-0001-8768-4801

John Sembrat (J)

Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Adriana S Leme (AS)

Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Kenny Ngo (K)

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States.

Olivia Morgenthaler (O)

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States.

Kellie Ha (K)

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States.

Bifeng Gao (B)

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States.

William J Janssen (WJ)

Department of Medicine, National Jewish Health, Denver, CO, United States.

Maria C Basil (MC)

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, United States.
ORCID: 0000-0003-4716-1285

Corrine R Kliment (CR)

Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Edward Morrisey (E)

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Mareike Lehmann (M)

Comprehensive Pneumology Center (CPC)/Institute of Lung Health and Immunity (LHI), Helmholtz Munich; Member of the German Center for Lung Research (DZL), Munich, Germany.
Institute for Lung Research, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, Germany.
ORCID: 0000-0002-8601-8206

Christopher M Evans (CM)

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO, United States.
Co-senior authors.

Herbert B Schiller (HB)

Research Unit Precision Regenerative Medicine (PRM), Helmholtz Munich; Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.
Co-senior authors.

Melanie Königshoff (M)

Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, and Critical Care Medicine; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States koenigshoffm@upmc.edu.
Geriatric Research Education and Clinical Center (GRECC) at the VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Co-senior authors.
ORCID: 0000-0001-9414-5128

Classifications MeSH