DMXL2 is required for endocytosis and recycling of synaptic vesicles in auditory hair cells.

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
15 Aug 2024
Historique:
received: 24 07 2023
revised: 10 07 2024
accepted: 04 08 2024
medline: 16 8 2024
pubmed: 16 8 2024
entrez: 15 8 2024
Statut: aheadofprint

Résumé

Ribbon synapses of inner hair cells are uniquely designed for ultrafast and indefatigable neurotransmission of the sound. The molecular machinery ensuring the efficient, compensatory recycling of the synaptic vesicles, however, remains elusive. This study showed that hair cell knockout of murine

Identifiants

DOI: 10.1523/JNEUROSCI.1405-23.2024 PMID: 39147590
pubmed: 39147590
pii: JNEUROSCI.1405-23.2024
doi: 10.1523/JNEUROSCI.1405-23.2024
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 Peng et al.

Auteurs

Hu Peng (H)

Department of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Longhao Wang (L)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Yunge Gao (Y)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Huihui Liu (H)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Guotong Lin (G)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Yu Kong (Y)

Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.

Pengcheng Xu (P)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Hongchao Liu (H)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Qingyue Yuan (Q)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Huanhai Liu (H)

Department of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.

Lei Song (L)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Tao Yang (T)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China yangtfxl@sina.com wuhao@shsmu.edu.cn.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Hao Wu (H)

Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China yangtfxl@sina.com wuhao@shsmu.edu.cn.
Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.

Classifications MeSH