Discovery of Novel (5-Mercapto-4-phenyl-4

crop safety herbicidal activity linker modification phytoene desaturase scaffold hopping

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
15 Aug 2024
Historique:
medline: 16 8 2024
pubmed: 16 8 2024
entrez: 15 8 2024
Statut: aheadofprint

Résumé

Phytoene desaturase (PDS) is a key rate-limiting enzyme in the carotenoid biosynthesis pathway. Although commercial PDS inhibitors have been developed for decades, it remains necessary to develop novel PDS inhibitors with higher bioactivity. In this work, we used the scaffold hopping and linker modification approaches to design and synthesize a series of compounds (

Identifiants

DOI: 10.1021/acs.jafc.4c05989 PMID: 39147603
pubmed: 39147603
doi: 10.1021/acs.jafc.4c05989
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Di Zhang (D)

National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China.

Chunxue Wang (C)

National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China.

Yichi Zhang (Y)

National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China.

Zhilei Yu (Z)

National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China.

Zeyu Hong (Z)

National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China.

Ding Jia (D)

National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China.

Dejun Ma (D)

National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China.
ORCID: 0000-0001-8800-5356

Yucheng Gu (Y)

Syngenta Jealott's Hill International Research Centre, Bracknell RG42 6EY, U.K.
ORCID: 0000-0002-6400-6167

Han Xu (H)

National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China.

Zhen Xi (Z)

National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China.
ORCID: 0000-0002-3332-5413

Classifications MeSH