The Role of 3' Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia.

Schizophrenia is often associated with volumetric reductions in cortices and expansions in basal ganglia, particularly the putamen. Recent genome-wide association studies have highlighted the significance of variants in the 3' regulatory region adjacent to the kinectin 1 gene ( We analyzed 1136 single-nucleotide polymorphisms (SNPs) covering the entire 3' regulatory region in 4 independent dbGaP samples (4604 schizophrenia patients vs. 4884 healthy subjects) and 3 independent Psychiatric Genomics Consortium samples (107 240 cases vs. 210 203 controls) to identify consistent associations. Additionally, we examined the regulatory effects of schizophrenia-associated alleles on The major alleles ( Our findings identify significant and functionally relevant risk alleles in the 3' regulatory region adjacent to

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2024 authors.

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Declaration of Interests: The authors have no conflicts of interest to declare.