A machine learning framework to classify musculoskeletal injury risk groups in military service members.

Cox proportional hazard regression decision trees screening secondary data survival

Journal

Frontiers in artificial intelligence
ISSN: 2624-8212
Titre abrégé: Front Artif Intell
Pays: Switzerland
ID NLM: 101770551

Informations de publication

Date de publication:
2024
Historique:
received: 19 04 2024
accepted: 27 05 2024
medline: 16 8 2024
pubmed: 16 8 2024
entrez: 16 8 2024
Statut: epublish

Résumé

Musculoskeletal injuries (MSKIs) are endemic in military populations. Thus, it is essential to identify and mitigate MSKI risks. Time-to-event machine learning models utilizing self-reported questionnaires or existing data (e.g., electronic health records) may aid in creating efficient risk screening tools. A total of 4,222 U.S. Army Service members completed a self-report MSKI risk screen as part of their unit's standard in-processing. Additionally, participants' MSKI and demographic data were abstracted from electronic health record data. Survival machine learning models (Cox proportional hazard regression (COX), COX with splines, conditional inference trees, and random forest) were deployed to develop a predictive model on the training data (75%; The COX model demonstrated the best model performance over the time horizons. The time-dependent area under the curve ranged from 0.73 to 0.70 at 30 and 180 days. The index prediction accuracy (IPA) was 12% better at 180 days than the IPA of the null model (0 variables). Within the COX model, "other" race, more self-reported pain items during the movement screens, female gender, and prior MSKI demonstrated the largest hazard ratios. When predicted probability was binned into quartiles, at 180 days, the highest risk bin had an MSKI incidence rate of 2,130.82 ± 171.15 per 1,000 person-years and incidence rate ratio of 4.74 (95% confidence interval: 3.44, 6.54) compared to the lowest risk bin. Self-reported questionnaires and existing data can be used to create a machine learning algorithm to identify Service members' MSKI risk profiles. Further research should develop more granular Service member-specific MSKI screening tools and create MSKI risk mitigation strategies based on these screenings.

Sections du résumé

Background UNASSIGNED
Musculoskeletal injuries (MSKIs) are endemic in military populations. Thus, it is essential to identify and mitigate MSKI risks. Time-to-event machine learning models utilizing self-reported questionnaires or existing data (e.g., electronic health records) may aid in creating efficient risk screening tools.
Methods UNASSIGNED
A total of 4,222 U.S. Army Service members completed a self-report MSKI risk screen as part of their unit's standard in-processing. Additionally, participants' MSKI and demographic data were abstracted from electronic health record data. Survival machine learning models (Cox proportional hazard regression (COX), COX with splines, conditional inference trees, and random forest) were deployed to develop a predictive model on the training data (75%;
Results UNASSIGNED
The COX model demonstrated the best model performance over the time horizons. The time-dependent area under the curve ranged from 0.73 to 0.70 at 30 and 180 days. The index prediction accuracy (IPA) was 12% better at 180 days than the IPA of the null model (0 variables). Within the COX model, "other" race, more self-reported pain items during the movement screens, female gender, and prior MSKI demonstrated the largest hazard ratios. When predicted probability was binned into quartiles, at 180 days, the highest risk bin had an MSKI incidence rate of 2,130.82 ± 171.15 per 1,000 person-years and incidence rate ratio of 4.74 (95% confidence interval: 3.44, 6.54) compared to the lowest risk bin.
Conclusion UNASSIGNED
Self-reported questionnaires and existing data can be used to create a machine learning algorithm to identify Service members' MSKI risk profiles. Further research should develop more granular Service member-specific MSKI screening tools and create MSKI risk mitigation strategies based on these screenings.

Identifiants

pubmed: 39149163
doi: 10.3389/frai.2024.1420210
pmc: PMC11325721
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1420210

Informations de copyright

Copyright © 2024 Bird, Roach, Nelson, Helton and Mauntel.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Matthew B Bird (MB)

Extremity Trauma and Amputation Center of Excellence, Defense Health Agency, Falls Church, VA, United States.
Department of Clinical Investigations, Womack Army Medical Center, Fort Liberty, NC, United States.

Megan H Roach (MH)

Extremity Trauma and Amputation Center of Excellence, Defense Health Agency, Falls Church, VA, United States.
Department of Clinical Investigations, Womack Army Medical Center, Fort Liberty, NC, United States.
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Roberts G Nelson (RG)

Artificial Intelligence Integration Center, Army Futures Command, Pittsburgh, PA, United States.

Matthew S Helton (MS)

U.S. Army, Tripler Army Medical Center, Honolulu, HI, United States.

Timothy C Mauntel (TC)

Extremity Trauma and Amputation Center of Excellence, Defense Health Agency, Falls Church, VA, United States.
Department of Clinical Investigations, Womack Army Medical Center, Fort Liberty, NC, United States.
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Classifications MeSH