Chitinase 3-Like 1 and C-X-C motif chemokine ligand 5 proteins and the hair cycle.
Animals
Mice
Hair Follicle
/ metabolism
Chitinase-3-Like Protein 1
/ metabolism
Cell Proliferation
Chemokine CXCL5
/ metabolism
Testosterone
/ metabolism
Estradiol
/ metabolism
Alopecia
/ metabolism
Male
Disease Models, Animal
Hair
/ growth & development
Coculture Techniques
Humans
Mitomycin
/ pharmacology
Signal Transduction
Cells, Cultured
Mice, Inbred C57BL
CHI3L1
CXCL5
Cell culture
Hair cycle
Hair growth
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
16 Aug 2024
16 Aug 2024
Historique:
received:
15
11
2023
accepted:
19
05
2024
revised:
13
05
2024
medline:
16
8
2024
pubmed:
16
8
2024
entrez:
16
8
2024
Statut:
epublish
Résumé
Dermal papilla cells (DPCs) exhibit self-recovery ability, which may be involved in hair growth. Therefore, we tested whether DPCs subjected to temporary growth-inhibiting stress (testosterone, 17β-estradiol, mitomycin C, or undernutrition) treatments exhibit self-recovery behavior that can activate hair follicle growth, and examined the changes in cell proliferation capacity and gene expression. Related proteins were identified and their relationships with the hair cycle was examined using a mouse model. Recovery-period DPCs (i.e., from day 3 after loading) were subjected to microarray analysis to detect genetic variations common to each stress treatment. Co-culture of recovery-period DPCs and outer root sheath cells (ORSCs) confirmed the promotion of ORSC proliferation, suggesting that the activation of hair follicle growth is promoted via signal transduction. Chitinase 3-like 1 (CHI3L1) and C-X-C motif chemokine 5 (CXCL5) exhibited ORSC proliferation-promoting effects. Measurement of protein content in the skin during each phase of the hair cycle in mice revealed that CHI3L1 and CXCL5 secretion increased immediately after anagen transition. In a hair-loss mouse model treated with testosterone or 17β-estradiol, CHI3L1 and CXCL5 secretion was lower in treated telogen skin than in untreated skin. Our results suggest that CHI3L1 and CXCL5 secreted by recovery-state DPCs promote hair growth.
Identifiants
pubmed: 39150635
doi: 10.1007/s00403-024-03151-5
pii: 10.1007/s00403-024-03151-5
doi:
Substances chimiques
Chitinase-3-Like Protein 1
0
Chemokine CXCL5
0
Testosterone
3XMK78S47O
Chil1 protein, mouse
0
Estradiol
4TI98Z838E
Mitomycin
50SG953SK6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
523Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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