Mice lacking

Animals Mice, Knockout Mice Autism Spectrum Disorder / metabolism Purkinje Cells / metabolism Cerebellum / metabolism Behavior, Animal / physiology Nerve Tissue Proteins / metabolism Disease Models, Animal Membrane Proteins / metabolism Male
ASTN2 Purkinje cell autism spectrum disorder cerebellum neurodevelopmental disorder

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
20 Aug 2024
Historique:
medline: 16 8 2024
pubmed: 16 8 2024
entrez: 16 8 2024
Statut: ppublish

Résumé

Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. Individuals with

Identifiants

DOI: 10.1073/pnas.2405901121 PMID: 39150780
pubmed: 39150780
doi: 10.1073/pnas.2405901121
doi:

Substances chimiques

Nerve Tissue Proteins 0
Membrane Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2405901121

Subventions

Organisme : HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : 5R01NS116089
Organisme : HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : R01NS128054 R01NS112917
Organisme : HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
ID : P50HD103525
Organisme : Sigrid Juselius Foundation
ID : Fellowship
Organisme : Leon Levy Foundation
ID : Fellowship
Organisme : NCATS NIH HHS
ID : UL1 TR000043
Pays : United States

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Michalina Hanzel (M)

Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.

Kayla Fernando (K)

Neurobiology Department, Duke University, Durham, NC 27710.

Susan E Maloney (SE)

Department of Psychiatry and the Intellectual and Developmental Disabilities Research Center, Washington University Medical School, St. Louis, MO 63130.
ORCID: 0000-0001-5585-4722

Zachi Horn (Z)

Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.
InVitro Cell Research LLC, Englewood, NJ 07631.

Shiaoching Gong (S)

Helen and Robert Appel Alzheimer's Disease Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10021.

Kärt Mätlik (K)

Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.
ORCID: 0000-0003-1777-5614

Jiajia Zhao (J)

Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.
ORCID: 0000-0003-3046-5362

H Amalia Pasolli (HA)

Electron Microscopy Resource Center, The Rockefeller University, New York, NY 10065.

Søren Heissel (S)

Proteomics Resource Center, The Rockefeller University, New York, NY 10065.

Joseph D Dougherty (JD)

Department of Psychiatry and the Intellectual and Developmental Disabilities Research Center, Washington University Medical School, St. Louis, MO 63130.
Department of Genetics, Washington University Medical School, St. Louis, MO 63130.
ORCID: 0000-0002-6385-3997

Court Hull (C)

Neurobiology Department, Duke University, Durham, NC 27710.
ORCID: 0000-0002-0360-8367

Mary E Hatten (ME)

Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065.
ORCID: 0000-0001-9059-660X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mice lacking
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Mice lacking
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mice lacking
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Mice lacking
questionsmedicales.fr › Cellules › Neurones › Cellules de Purkinje › Mice lacking
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Métencéphale › Cervelet › Mice lacking
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Mice lacking
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Mice lacking
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Mice lacking
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Mice lacking