Effect of different anticoagulants and antiplatelets on intraoral bleeding time during professional oral hygiene session.
Humans
Anticoagulants
/ therapeutic use
Female
Male
Platelet Aggregation Inhibitors
/ therapeutic use
Middle Aged
Bleeding Time
Oral Hemorrhage
/ prevention & control
Aged
Adult
Oral Hygiene
Dabigatran
/ therapeutic use
Factor Xa Inhibitors
/ therapeutic use
Warfarin
/ therapeutic use
Clopidogrel
/ therapeutic use
Pyrazoles
/ therapeutic use
Aspirin
/ adverse effects
Rivaroxaban
/ therapeutic use
Anticoagulant
Antiplatelet
Dental hygiene
Oral bleeding
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
17 Aug 2024
17 Aug 2024
Historique:
received:
19
04
2024
accepted:
13
08
2024
medline:
18
8
2024
pubmed:
18
8
2024
entrez:
17
8
2024
Statut:
epublish
Résumé
Patients with thromboembolic problems, prosthetic valves, or coagulation issues are commonly prescribed anticoagulants and antiplatelets. Anticoagulant and antiplatelet medication might constitute a challenge for dentists and dental hygienists since possible prolonged bleeding might interfere with dental procedures. The aim of the present study was to examine the bleeding durations associated with various anticoagulants and antiplatelets during professional dental hygiene sessions, utilizing a modified Ivy test adapted for the oral context. Ninety-three consecutive patients undergoing professional oral hygiene were recruited. Debridement during oral hygiene was performed using ultrasonic mechanical instrumentation, and bleeding sites were assessed and treated with gentle pressure using sterile gauzes. The time for bleeding cessation was recorded. Patients were categorized into six groups based on their drug intake, Control: no anticoagulants or antiplatelets DTI: direct thrombin inhibitors (dabigatran) AntiXa: directa factor Xa inhibitors (endoxaban, apixaban, rivaroxaban) VKA: vitamin K antagonists (warfarin, acenocoumarol) SAPT: single anti-platelet therapy (acetylsalicylic acid or clopidogrel) DAPT: dual anti-platelet therapy (acetylsalicylic acid and clopidogrel). Bleeding time was measured in seconds and mean values were assessed among the different groups. Differences between groups were investigated with Kruskal-Wallis test followed by Dunn's post-hoc correction for multiple comparisons or two-way ANOVA followed by Dunnett post-hoc; RESULTS: Control patients presented the lowest bleeding time 50 s, followed by AntiXa (98), SAPT (105), DTI (120), DAPT (190) and VKA (203). A statistically significant difference was present among control and DTI (p = 0.004), VKA (p < 0.001), DAPT (p < 0.001). Based on the present outcomes, an increased risk of prolonged bleeding emerged in patients taking VKA and DAPT. bleeding did not interfere with the oral hygiene session The optimal period for dental treatment of these patients should be 2-3 h before the next dose, without the need to temporarily suspend the medication.
Identifiants
pubmed: 39154023
doi: 10.1186/s12903-024-04738-0
pii: 10.1186/s12903-024-04738-0
doi:
Substances chimiques
Anticoagulants
0
Platelet Aggregation Inhibitors
0
Dabigatran
I0VM4M70GC
Factor Xa Inhibitors
0
Warfarin
5Q7ZVV76EI
Clopidogrel
A74586SNO7
Pyrazoles
0
Aspirin
R16CO5Y76E
Rivaroxaban
9NDF7JZ4M3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
957Informations de copyright
© 2024. The Author(s).
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