Changes in absolute coronary flow and microvascular resistance during exercise in patients with ANOCA.
Humans
Male
Middle Aged
Female
Coronary Circulation
/ physiology
Vascular Resistance
Aged
Coronary Artery Disease
/ physiopathology
Exercise Test
Exercise
/ physiology
Microcirculation
/ physiology
Hyperemia
/ physiopathology
Coronary Vessels
/ physiopathology
Fractional Flow Reserve, Myocardial
/ physiology
Angina Pectoris
/ physiopathology
Journal
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
ISSN: 1969-6213
Titre abrégé: EuroIntervention
Pays: France
ID NLM: 101251040
Informations de publication
Date de publication:
19 Aug 2024
19 Aug 2024
Historique:
medline:
19
8
2024
pubmed:
19
8
2024
entrez:
19
8
2024
Statut:
ppublish
Résumé
Whether saline-induced hyperaemia captures exercise-induced coronary flow regulation remains unknown. Through this study, we aimed to describe absolute coronary flow (Q) and microvascular resistance (Rμ) adaptation during exercise in participants with angina with non-obstructive coronary artery disease (ANOCA) and to explore the correlations between saline- and exercise-derived coronary flow reserve (CFR) and microvascular resistance reserve (MRR). Rμ, Q, CFR and MRR were assessed in the left anterior descending artery using continuous thermodilution with saline infusion at 10 mL/min (rest), 20 mL/min (hyperaemia) and finally at a 10 mL/min infusion rate during stress testing with a dedicated supine cycling ergometer. An incremental workload of 30 watts every two minutes was applied. A saline-derived CFR (CFR CFR Saline-induced hyperaemia provided a valid surrogate for exercise physiology independently of the absolute level of CFR and MRR, although exercise provided more granularity to evaluate adaptation among participants with exercise-related CMD.
Sections du résumé
BACKGROUND
BACKGROUND
Whether saline-induced hyperaemia captures exercise-induced coronary flow regulation remains unknown.
AIMS
OBJECTIVE
Through this study, we aimed to describe absolute coronary flow (Q) and microvascular resistance (Rμ) adaptation during exercise in participants with angina with non-obstructive coronary artery disease (ANOCA) and to explore the correlations between saline- and exercise-derived coronary flow reserve (CFR) and microvascular resistance reserve (MRR).
METHODS
METHODS
Rμ, Q, CFR and MRR were assessed in the left anterior descending artery using continuous thermodilution with saline infusion at 10 mL/min (rest), 20 mL/min (hyperaemia) and finally at a 10 mL/min infusion rate during stress testing with a dedicated supine cycling ergometer. An incremental workload of 30 watts every two minutes was applied. A saline-derived CFR (CFR
RESULTS
RESULTS
CFR
CONCLUSIONS
CONCLUSIONS
Saline-induced hyperaemia provided a valid surrogate for exercise physiology independently of the absolute level of CFR and MRR, although exercise provided more granularity to evaluate adaptation among participants with exercise-related CMD.
Identifiants
pubmed: 39155757
pii: EIJ-D-24-00247
doi: 10.4244/EIJ-D-24-00247
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM