Small cell lung carcinoma with

Anlotinib Case report KIF5B-RET fusion Next-generation sequencing Partial response Small cell lung cancer

Journal

World journal of clinical cases
ISSN: 2307-8960
Titre abrégé: World J Clin Cases
Pays: United States
ID NLM: 101618806

Informations de publication

Date de publication:
16 Aug 2024
Historique:
received: 31 03 2024
revised: 12 06 2024
accepted: 25 06 2024
medline: 19 8 2024
pubmed: 19 8 2024
entrez: 19 8 2024
Statut: ppublish

Résumé

Small cell lung cancer (SCLC) exhibits a pronounced tendency for metastasis and relapse, and the acquisition of resistance to chemotherapy and radiotherapy, leading to complexity in treatment outcomes. It is crucial to tackle these challenges by advancing targeted therapeutic approaches in ongoing research endeavors. Variant RET fusions have been reported in several solid tumors, but are rarely reported in SCLC. We present the first case of a NGS can provide SCLC patients with personalized and targeted therapy options, thereby improving their likelihood of survival.

Sections du résumé

BACKGROUND BACKGROUND
Small cell lung cancer (SCLC) exhibits a pronounced tendency for metastasis and relapse, and the acquisition of resistance to chemotherapy and radiotherapy, leading to complexity in treatment outcomes. It is crucial to tackle these challenges by advancing targeted therapeutic approaches in ongoing research endeavors. Variant RET fusions have been reported in several solid tumors, but are rarely reported in SCLC.
CASE SUMMARY METHODS
We present the first case of a
CONCLUSION CONCLUSIONS
NGS can provide SCLC patients with personalized and targeted therapy options, thereby improving their likelihood of survival.

Identifiants

DOI: 10.12998/wjcc.v12.i23.5410 PMID: 39156099 PMC: PMC11238689
pubmed: 39156099
doi: 10.12998/wjcc.v12.i23.5410
pmc: PMC11238689
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Pagination

5410-5415

Informations de copyright

©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Auteurs

Rui Zhang (R)

Meat Processing Key Laboratory of Sichuan Province, College of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan Province, China.

Yu-Ting He (YT)

School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China.

Yi-Sha Liu (YS)

Department of Pathology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China.

Hang Li (H)

Department of Radiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China.

Feng Zhao (F)

Department of Oncology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China. zhaofengzl@med.uestc.edu.cn.

Classifications MeSH