Amphiregulin orchestrates the paracrine immune-suppressive function of amniotic-derived cells through its interplay with COX-2/PGE

Cell biology Immune response Molecular biology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
16 Aug 2024
Historique:
received: 06 03 2024
revised: 10 06 2024
accepted: 11 07 2024
medline: 19 8 2024
pubmed: 19 8 2024
entrez: 19 8 2024
Statut: epublish

Résumé

The paracrine crosstalk between amniotic-derived membranes (AMs)/epithelial cells (AECs) and immune cells is pivotal in tissue healing following inflammation. Despite evidence collected to date, gaps in understanding the underlying molecular mechanisms have hindered clinical applications. The present study represents a significant step forward demonstrating that amphiregulin (AREG) orchestrates the native immunomodulatory functions of amniotic derivatives via the COX-2/PGE

Identifiants

DOI: 10.1016/j.isci.2024.110508 PMID: 39156643 PMC: PMC11326934
pubmed: 39156643
doi: 10.1016/j.isci.2024.110508
pii: S2589-0042(24)01733-4
pmc: PMC11326934
doi:

Types de publication

Journal Article

Langues

eng

Pagination

110508

Informations de copyright

© 2024 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Auteurs

Giuseppe Prencipe (G)

Unit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.

Adrián Cerveró-Varona (A)

Unit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.

Monia Perugini (M)

Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Teramo, Italy.

Ludovica Sulcanese (L)

Unit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.

Annamaria Iannetta (A)

Department of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Teramo, Italy.

Arlette Alina Haidar-Montes (AA)

Unit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.

Johannes Stöckl (J)

Centre for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Medical University of Vienna, Vienna 1090, Austria.

Angelo Canciello (A)

Unit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.

Paolo Berardinelli (P)

Unit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.

Valentina Russo (V)

Unit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.

Barbara Barboni (B)

Unit of Basic and Applied Sciences, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.

Classifications MeSH