Correlation between local instantaneous dose rate and oxygen pressure reduction during proton pencil beam scanning irradiation.
Oxygen consumption g-value
Oxygen dynamics
Phosphorescence quenching
Proton pencil beam scanning
Journal
Physics and imaging in radiation oncology
ISSN: 2405-6316
Titre abrégé: Phys Imaging Radiat Oncol
Pays: Netherlands
ID NLM: 101704276
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
received:
29
05
2024
revised:
13
07
2024
accepted:
16
07
2024
medline:
19
8
2024
pubmed:
19
8
2024
entrez:
19
8
2024
Statut:
epublish
Résumé
Oxygen dynamics may be important for the tissue-sparing effect observed at ultra-high dose rates (FLASH sparing effect). This study investigated the correlation between local instantaneous dose rate and radiation-induced oxygen pressure reduction during proton pencil beam scanning (PBS) irradiations of a sample and quantified the oxygen consumption g-value. A 0.2 ml phosphorescent sample (1 μM PtG4 Oxyphor probe in saline) was irradiated with a 244 MeV proton PBS beam. Four irradiations were performed with variations of a PBS spot pattern with 5 × 7 spots. During irradiation, the partial oxygen pressure (pO A high correlation was found between the local instantaneous dose rate and pO The pO
Sections du résumé
Background and purpose
UNASSIGNED
Oxygen dynamics may be important for the tissue-sparing effect observed at ultra-high dose rates (FLASH sparing effect). This study investigated the correlation between local instantaneous dose rate and radiation-induced oxygen pressure reduction during proton pencil beam scanning (PBS) irradiations of a sample and quantified the oxygen consumption g-value.
Materials and methods
UNASSIGNED
A 0.2 ml phosphorescent sample (1 μM PtG4 Oxyphor probe in saline) was irradiated with a 244 MeV proton PBS beam. Four irradiations were performed with variations of a PBS spot pattern with 5 × 7 spots. During irradiation, the partial oxygen pressure (pO
Results
UNASSIGNED
A high correlation was found between the local instantaneous dose rate and pO
Conclusions
UNASSIGNED
The pO
Identifiants
pubmed: 39157294
doi: 10.1016/j.phro.2024.100614
pii: S2405-6316(24)00084-8
pmc: PMC11327481
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100614Informations de copyright
© 2024 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.