Effect of emergent nephrostomy on long-term total and split renal function in patients with upper urinary tract obstruction due to pelvic malignant tumors.
Humans
Female
Male
Ureteral Obstruction
/ surgery
Hydronephrosis
/ etiology
Retrospective Studies
Child
Pelvic Neoplasms
/ surgery
Adolescent
Child, Preschool
Glomerular Filtration Rate
/ physiology
Kidney
/ physiopathology
Treatment Outcome
Nephrostomy, Percutaneous
/ methods
Kidney Function Tests
/ methods
Infant
Childhood cancer
Nephrostomy
Pelvic malignant tumor
Split renal function
Upper urinary tract obstruction
Journal
Pediatric surgery international
ISSN: 1437-9813
Titre abrégé: Pediatr Surg Int
Pays: Germany
ID NLM: 8609169
Informations de publication
Date de publication:
19 Aug 2024
19 Aug 2024
Historique:
accepted:
07
08
2024
medline:
19
8
2024
pubmed:
19
8
2024
entrez:
19
8
2024
Statut:
epublish
Résumé
This study aimed to investigate the impact of nephrostomies on the outcome of total renal function (TRF) and split renal function (SRF) in patients with malignant pelvic tumors associated with upper urinary tract obstruction (UUTO). Patients with pelvic tumors suffering severe unilateral hydronephrosis treated at our hospital from 2000 to 2022 were included. Data for nephrostomy placement, short- and long-term renal function, and radiological and nuclear imaging studies were collected. The TRF and SRF of patients who underwent nephrostomy were compared to those who did not. Seven patients were included (rhabdomyosarcoma: 5, ovarian germ cell tumor: 1, malignant rhabdoid tumor: 1). Nephrostomies were placed in four, which were successfully managed without severe infections. Estimated glomerular filtration rate (eGFR) was significantly improved at the end of treatment in patients with nephrostomy. In contrast, eGFR in patients who did not undergo nephrostomy was not improved. Nuclear imaging studies (renograms or renal scintigrams) revealed impaired SRF of the affected kidney compared to the contralateral kidney, even in patients whose eGFR was within normal levels. Notably, SRF showed a trend to improve over time in one patient treated with nephrostomy. Nephrostomy for UUTO caused by pelvic tumors may improve renal outcome.
Identifiants
pubmed: 39158590
doi: 10.1007/s00383-024-05810-0
pii: 10.1007/s00383-024-05810-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
234Informations de copyright
© 2024. The Author(s).
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