The Hemagglutinin of Influenza A Virus Induces Ferroptosis to Facilitate Viral Replication.
autophagy
ferroptosis
influenza a virus
innate immunity
mitochondrial antiviral signaling protein (MAVS)
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
19 Aug 2024
19 Aug 2024
Historique:
revised:
27
07
2024
received:
24
04
2024
medline:
19
8
2024
pubmed:
19
8
2024
entrez:
19
8
2024
Statut:
aheadofprint
Résumé
Ferroptosis is a novel form of cell death caused by the accumulation of lipid peroxides in an iron-dependent manner. However, the precise mechanism underlying the exploitation of ferroptosis by influenza A viruses (IAV) remains unclear. The results demonstrate that IAV promotes its own replication through ferritinophagy by sensitizing cells to ferroptosis, with hemagglutinin identified as a key trigger in this process. Hemagglutinin interacts with autophagic receptors nuclear receptor coactivator 4 (NCOA4) and tax1-binding protein 1 (TAX1BP1), facilitating the formation of ferritin-NCOA4 condensates and inducing ferritinophagy. Further investigation shows that hemagglutinin-induced ferritinophagy causes cellular lipid peroxidation, inhibits aggregation of mitochondrial antiviral signaling protein (MAVS), and suppresses the type I interferon response, thereby contributing to viral replication. Collectively, a novel mechanism by which IAV hemagglutinin induces ferritinophagy resulting in cellular lipid peroxidation, consequently impairing MAVS-mediated antiviral immunity, is revealed.
Identifiants
pubmed: 39159143
doi: 10.1002/advs.202404365
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2404365Subventions
Organisme : National Natural Science Foundation of China
ID : 32025036
Organisme : National Natural Science Foundation of China
ID : 3240190410
Organisme : National Key Research and Development Program
ID : 2021YFD1800204
Organisme : Fundamental Research Fund for the Central Universities
ID : 2662023PY005
Organisme : Hubei Hongshan Laboratory
ID : 2022hszd005
Organisme : The earmarked fund for CARS-41
Organisme : Natural Science Foundation of Hubei Province
ID : 2021CFA016
Informations de copyright
© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
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