In through the out door: A loop-binding-first model for topological cohesin loading.

SMC complex chromosome cohesion cohesin

Journal

BioEssays : news and reviews in molecular, cellular and developmental biology

ISSN: 1521-1878

Titre abrégé: Bioessays

Pays: United States

ID NLM: 8510851

Informations de publication

Date de publication:
19 Aug 2024

Historique:

revised: 04 08 2024

received: 26 05 2024

accepted: 09 08 2024

medline: 19 8 2024

pubmed: 19 8 2024

entrez: 19 8 2024

Statut: aheadofprint

Résumé

Cohesin is a ring-shaped complex that is loaded on DNA in two different conformations. In one conformation, it forms loops to organize the interphase genome; in the other, it topologically encircles sibling chromosomes to facilitate homologous recombination and to establish the cohesion that is required for orderly segregation during mitosis. How, and even if, these two loading conformation are related is unclear. Here, I propose that loop binding is a required first step for topological binding. This loop-binding-first model integrates the known information about the two loading mechanisms, explains genetic requirements for the two and explains how topological loading evolved from loop binding.

Identifiants

DOI: 10.1002/bies.202400120 PMID: 39159466

pubmed: 39159466

doi: 10.1002/bies.202400120

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

e2400120

Subventions

Organisme : NIGMS NIH HHS

ID : R35GM148359

Pays : United States

Informations de copyright

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