Radiosynthesis and preclinical evaluation of a

68Ga Bifunctional chelator (BFC) CXCR4 receptor Glioblastoma (GBM) PET tracer Positron emission tomography

Journal

EJNMMI radiopharmacy and chemistry
ISSN: 2365-421X
Titre abrégé: EJNMMI Radiopharm Chem
Pays: England
ID NLM: 101714628

Informations de publication

Date de publication:
20 Aug 2024
Historique:
received: 07 06 2024
accepted: 30 07 2024
medline: 20 8 2024
pubmed: 20 8 2024
entrez: 20 8 2024
Statut: epublish

Résumé

This study aimed to develop a novel positron emission tomography (PET) tracer, [ A bifunctional chelator was prepared by conjugating the amine group of TIQ15 with p-NCS-Bz-DOTA, yielding TD-01, with a high yield (68.92%). TD-01 was then radiolabeled with [ The newly developed CXCR4 PET tracer, [

Sections du résumé

BACKGROUND BACKGROUND
This study aimed to develop a novel positron emission tomography (PET) tracer, [
METHODS METHODS
A bifunctional chelator was prepared by conjugating the amine group of TIQ15 with p-NCS-Bz-DOTA, yielding TD-01, with a high yield (68.92%). TD-01 was then radiolabeled with
RESULTS RESULTS
[
CONCLUSION CONCLUSIONS
The newly developed CXCR4 PET tracer, [

Identifiants

pubmed: 39162901
doi: 10.1186/s41181-024-00290-y
pii: 10.1186/s41181-024-00290-y
doi:

Types de publication

Journal Article

Langues

eng

Pagination

61

Subventions

Organisme : National Research Council of Thailand
ID : The National Research Council of Thailand (NRCT) under Molecular Probes for Imaging International Research Network (IRN N10A650046) (O.V.)
Organisme : Graduate School, Chulalongkorn University
ID : 100th Anniversary Chulalongkorn University Fund for Doctoral Scholarship
Organisme : Graduate School, Chulalongkorn University
ID : 90th Anniversary of Chulalongkorn University Scholarship (GCUGR1125652013D)
Organisme : Trond Mohn Foundation (TMF) and Helse-Nord grant
ID : Trond Mohn Foundation (TMF)
Organisme : Trond Mohn Foundation (TMF) and Helse-Nord grant
ID : Helse-Nord grant HNF1591-21/HNF1695-23

Informations de copyright

© 2024. The Author(s).

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Auteurs

Piyapan Suwattananuruk (P)

Department of Food and Pharmaceutical Chemistry and Center of Excellence in Natural Products for Ageing and Chronic Diseases, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Molecular Probes for Imaging Research Network, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

Sukanya Yaset (S)

National Cyclotron and PET Centre, Chulabhorn Hospital, Bangkok, Thailand.

Chanisa Chotipanich (C)

National Cyclotron and PET Centre, Chulabhorn Hospital, Bangkok, Thailand.

Angel Moldes-Anaya (A)

PET Imaging Center, University Hospital of North Norway, Tromsø, Norway.

Rune Sundset (R)

PET Imaging Center, University Hospital of North Norway, Tromsø, Norway.
Department of Clinical Medicine, Nuclear Medicine and Radiation Biology Research Group, UiT The Arctic University of Norway, Tromsø, Norway.

Rodrigo Berzaghi (R)

Department of Clinical Medicine, Nuclear Medicine and Radiation Biology Research Group, UiT The Arctic University of Norway, Tromsø, Norway.

Stine Figenschau (S)

Department of Clinical Medicine, Nuclear Medicine and Radiation Biology Research Group, UiT The Arctic University of Norway, Tromsø, Norway.

Sandra Claes (S)

Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, KU Leuven, Louvain, Belgium.

Dominique Schols (D)

Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, KU Leuven, Louvain, Belgium.

Pornchai Rojsitthisak (P)

Department of Food and Pharmaceutical Chemistry and Center of Excellence in Natural Products for Ageing and Chronic Diseases, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Molecular Probes for Imaging Research Network, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.

Mathias Kranz (M)

PET Imaging Center, University Hospital of North Norway, Tromsø, Norway. mathias.kranz@uit.no.
Department of Clinical Medicine, Nuclear Medicine and Radiation Biology Research Group, UiT The Arctic University of Norway, Tromsø, Norway. mathias.kranz@uit.no.

Opa Vajragupta (O)

Department of Food and Pharmaceutical Chemistry and Center of Excellence in Natural Products for Ageing and Chronic Diseases, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. Opa.V@chula.ac.th.
Molecular Probes for Imaging Research Network, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. Opa.V@chula.ac.th.

Classifications MeSH