Role of sirtuins in sepsis and sepsis-induced organ dysfunction: A review.
Agonists
Inhibitors
Organ dysfunction
Post-translational modifications
Sepsis
Sirtuins
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
18 Aug 2024
18 Aug 2024
Historique:
received:
29
04
2024
revised:
16
08
2024
accepted:
16
08
2024
medline:
21
8
2024
pubmed:
21
8
2024
entrez:
20
8
2024
Statut:
aheadofprint
Résumé
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis causes a high mortality rate and current treatment focuses on supportive therapies but lacks specific therapeutic targets. Notably, sirtuins (SIRTs) shows potential clinical application in the treatment of sepsis. It has been demonstrated that SIRTs, the nicotinamide adenine dinucleotide
Identifiants
pubmed: 39163955
pii: S0141-8130(24)05658-7
doi: 10.1016/j.ijbiomac.2024.134853
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
134853Informations de copyright
Copyright © 2024 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no competing interests.