Possible Association between Behçet's Disease and Periodontal diseases.
Humans
Behcet Syndrome
/ complications
Gingival Crevicular Fluid
/ chemistry
Interleukin-1beta
/ analysis
Male
Female
Saliva
/ chemistry
Gingivitis
/ metabolism
Adult
Tumor Necrosis Factor-alpha
/ analysis
Nitric Oxide
/ metabolism
Periodontitis
/ complications
Periodontal Index
Middle Aged
Periodontal Pocket
Periodontal Attachment Loss
Young Adult
Behçet’s disease
Gingivitis
IL-1β
Nitric oxide
Periodontitis
TNF-α
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
20 Aug 2024
20 Aug 2024
Historique:
received:
23
02
2024
accepted:
14
08
2024
medline:
21
8
2024
pubmed:
21
8
2024
entrez:
20
8
2024
Statut:
epublish
Résumé
This study explores the connection between Behçet's disease (BD), characterized by persistent oral and genital ulcers alongside iritis, and periodontal disease. It examines the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nitric oxide (NO) in gingival crevicular fluid (GCF) and saliva. Forty Behçet's patients with gingivitis or periodontitis and 47 patients with either gingivitis or periodontitis but without BD were studied. Periodontal status was recorded with standard clinical indexes. GCF and saliva samples were obtained. NO, IL-1β and TNF-α levels were analysed. Current Behçet's symptoms and medications usage were recorded. Mean salivary IL-1β was elevated (p = .045), and mean NO level was decreased in BD patients with gingivitis compared to patients without BD (p = .000). In contrast, mean NO level in crevicular fluid was higher in Behçet's patients with periodontitis than in patients without BD (p = .009). Furthermore, among Behçet's patients, those with vascular involvement had lower salivary NO level compared to patients without vascular involvement (p = .000). Based on our findings, the elevated levels of IL-1β in the saliva of Behçet's patients with gingivitis, along with the decreased NO level, indicate an altered inflammatory response in the oral cavity.
Identifiants
pubmed: 39164726
doi: 10.1186/s12903-024-04749-x
pii: 10.1186/s12903-024-04749-x
doi:
Substances chimiques
Interleukin-1beta
0
Tumor Necrosis Factor-alpha
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
964Subventions
Organisme : Gazi Üniversitesi
ID : 03/2016-01
Organisme : Gazi Üniversitesi
ID : 03/2016-01
Organisme : Gazi Üniversitesi
ID : 03/2016-01
Informations de copyright
© 2024. The Author(s).
Références
Kurokawa MS, Yoshikawa H, Suzuki N. Behçet’s disease. In: Seminars in respiratory and critical care medicine. vol. 25: Copyright© 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, NewYork, 2004: 557–568.
Atzeni F, Giallanza M, Masala IF. Microorganisms in Pathogenesis and Management of Behçet Disease (BD). InRole of microorganisms in Pathogenesis and Management of Autoimmune diseases: volume II: kidney, Central Nervous System, Eye, blood, blood vessels & bowel 2023 Jan 1 (pp. 359–71). Singapore: Springer Nature Singapore.
Alpsoy E, Bozca BC, Bilgic A. Behçet disease: an update for dermatologists. Am J Clin Dermatol. 2021;4:477–502.
doi: 10.1007/s40257-021-00609-4
Martínez-García M, Hernández-Lemus E. Periodontal inflammation and systemic diseases: an overview. Front Physiol. 2021;27:709438.
doi: 10.3389/fphys.2021.709438
Mumcu G, Fortune F. Oral health and its aetiological role in Behçet’s disease. Front Med. 2021;20:613419.
doi: 10.3389/fmed.2021.613419
Abunemer RM, Shaheen RS, Alghamdi RA. Correlation of anti-TNF-a biological therapy with periodontal conditions and osteonecrosis in autoimmune patients: a systematic review. Saudi Dent J. 2023;35:785–96.
doi: 10.1016/j.sdentj.2023.07.006
Delima A, Oates T, Assuma R, et al. Soluble antagonists to interleukin-1 (IL‐1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis. J Clin Periodontol. 2001;28:233–40.
pubmed: 11284536
doi: 10.1034/j.1600-051x.2001.028003233.x
Mayer Y, Balbir-Gurman A, Machtei EE. Anti‐tumor necrosis factor‐alpha therapy and periodontal parameters in patients with rheumatoid arthritis. J Periodontol. 2009;80:1414–20.
pubmed: 19722791
doi: 10.1902/jop.2009.090015
Pers JO, Saraux A, Pierre R, Youinou P. Anti–TNF-α immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis. J Periodontol. 2008;79:1645–51.
pubmed: 18771364
doi: 10.1902/jop.2008.070616
Aral CA, Aral K, Yay A, Özçoban Ö, Berdeli A, Saraymen R. Effects of colchicine on gingival inflammation, apoptosis, and alveolar bone loss in experimental periodontitis. J Periodontol. 2018;89:577–85.
pubmed: 29520818
doi: 10.1002/JPER.17-0359
Liang L, Zhou Q, Feng L. Decreased microRNA-155 in Behcet’s disease leads to defective control of autophagy thereby stimulating excessive proinflammatory cytokine production. Arthritis Res Therapy. 2021;6:135.
doi: 10.1186/s13075-021-02517-8
Kozak M, Dabrowska-Zamojcin E, Mazurek-Mochol M, Pawlik A. Cytokines and their genetic polymorphisms related to periodontal disease. J Clin Med. 2020;9:4045.
pubmed: 33327639
pmcid: 7765090
doi: 10.3390/jcm9124045
Ozer L, Elgun S, Ozdemir B, Pervane B, Ozmeric N. Arginine–nitric oxide–polyamine metabolism in periodontal disease. J Periodontol. 2011;82:320–8.
pubmed: 20831369
doi: 10.1902/jop.2010.100199
Akman A, Ekinci NC, Kacaroglu H, Yavuzer U, Alpsoy E, Yegin O. Relationship between periodontal findings and specific polymorphisms of interleukin-1α and-1β in Turkish patients with Behçet’s disease. Arch Dermatol Res. 2008;300:19–26.
pubmed: 17960403
doi: 10.1007/s00403-007-0794-1
Akman A, Kacaroglu H, Donmez L, Bacanli A, Alpsoy E. Relationship between periodontal findings and Behçet’s disease: a controlled study. J Clin Periodontol. 2007;34:485–91.
pubmed: 17451414
doi: 10.1111/j.1600-051X.2007.01085.x
Papapanou PN, Sanz M, Buduneli N, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World workshop on the classification of Periodontal and Peri-implant diseases and conditions. J Periodontol. 2018;89:S173–82.
pubmed: 29926951
doi: 10.1002/JPER.17-0721
Trombelli L, Farina R, Silva CO, Tatakis DN. Plaque-induced gingivitis: case definition and diagnostic considerations. J Clin Periodontol. 2018;45:S44–67.
pubmed: 29926492
doi: 10.1111/jcpe.12939
Silness J, Löe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964;22:121–35.
pubmed: 14158464
doi: 10.3109/00016356408993968
Löe H, Silness J. Periodontal disease in pregnancy I. Prevalence and severity. Acta Odontol Scand. 1963;21:533–51.
pubmed: 14121956
doi: 10.3109/00016356309011240
Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J. 1975;25:229–35.
pubmed: 1058834
Jacob PS, Nath S, Patel RP. Evaluation of interleukin-1β and 8 in gutka chewers with periodontitis among a rural Indian population. J Periodontal Implant Sci. 2014;44:126.
pubmed: 24921056
pmcid: 4050229
doi: 10.5051/jpis.2014.44.3.126
Pandey V, Salam SA, Moda A, Agarwal P, Nath S, Pulikkotil SJ. Effect of the use of snuff on the levels of interleukin-1 β and interleukin-8 in the gingival crevicular fluid of periodontitis patients. Dent Res J. 2015;12:461–8.
doi: 10.4103/1735-3327.166222
Aydındoğan S, Velioğlu EM. Behçet’s disease and periodontal disease. Curr Oral Health Rep. 2023;10:52–8.
doi: 10.1007/s40496-023-00332-5
Wang M, Gao M, Yi Z. Biological effects of IL-33/ST2 axis on oral diseases: autoimmune diseases and periodontal diseases. Int Immunopharmacol. 2023;1:110524.
doi: 10.1016/j.intimp.2023.110524
Papathanasiou E, Conti P, Carinci F, Lauritano D, Theoharides TC. IL-1 superfamily members and periodontal diseases. J Dent Res. 2020;99:1425–34.
pubmed: 32758110
pmcid: 7684837
doi: 10.1177/0022034520945209
Akman A, Sallakci N, Coskun M, et al. TNF-α gene 1031 T/C polymorphism in Turkish patients with Behçet’s disease. Br J Dermatol. 2006;155:350–6.
pubmed: 16882174
doi: 10.1111/j.1365-2133.2006.07348.x
Türkcü FM, Şahin A, Cingü AK, et al. Serum omentin, resistin and tumour necrosis factor-α levels in Behçet patients with and without ocular involvement. Graefe’s Archive Clin Experimental Ophthalmol. 2015;253:1565–8.
doi: 10.1007/s00417-015-3016-0
Sakane T, Suzuki N, Nagafuchi H. Etiopathology of Behcet’s disease: immunological aspects. Yonsei Med J. 1997;38:350–8.
pubmed: 9509903
doi: 10.3349/ymj.1997.38.6.350
Uğar-Çankal D, Ozmeric N. A multifaceted molecule, nitric oxide in oral and periodontal diseases. Clin Chim Acta. 2006;366:90–100.
pubmed: 16387291
doi: 10.1016/j.cca.2005.10.018
Turkmen S, Ayabakan H, Buldanlioglu S, et al. Nitric oxide, lipid peroxidation and antioxidant defence system in patients with active or inactive Behçet’s disease. Br J Dermatol. 2005;153:526–30.
pubmed: 16120137
doi: 10.1111/j.1365-2133.2005.06543.x
Örem A, Vanizor B, Cimşit G, Kıran E, Değer O, Malkoç M. Decreased nitric oxide production in patients with Behçet’s disease. Dermatology. 1999;198:33–6.
pubmed: 10026399
doi: 10.1159/000018061
Bettiol A, Alibaz-Oner F, Direskeneli H, Hatemi G, Saadoun D, Seyahi E, Prisco D, Emmi G. Vascular Behçet syndrome: from pathogenesis to treatment. Nat Rev Rheumatol. 2023;19:111–26.
pubmed: 36544027
doi: 10.1038/s41584-022-00880-7
Lee Y, Song G. Associations between eNOS polymorphisms and susceptibility to Behçet’s disease: a meta-analysis. J Eur Acad Dermatol Venereol. 2012;26:1266–71.
pubmed: 21957880
doi: 10.1111/j.1468-3083.2011.04280.x
Buduneli N, Bıyıkoğlu B, Kinane DF. Utility of gingival crevicular fluid components for periodontal diagnosis. Periodontol 2000. 2024;00:1–20.
Oh H, Hirano J, Takai H, Ogata Y. Effects of initial periodontal therapy on interleukin-1β level in gingival crevicular fluid and clinical periodontal parameters. J Oral Sci. 2015;57:67–71.
pubmed: 26062853
doi: 10.2334/josnusd.57.67
Dongiovanni P, Meroni M, Casati S, Goldoni R, Thomaz DV, Kehr NS, Galimberti D, Del Fabbro M, Tartaglia GM. Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation. Int J Oral Sci. 2023;15:27.
pubmed: 37386003
pmcid: 10310701
doi: 10.1038/s41368-023-00231-6
Grant MM, Taylor JJ, Jaedicke K, Creese A, Gowland C, Burke B, Doudin K, Patel U, Weston P, Milward M, Bissett SM. Discovery, validation, and diagnostic ability of multiple protein-based biomarkers in saliva and gingival crevicular fluid to distinguish between health and periodontal diseases. J Clin Periodontol. 2022;49:622–32.
pubmed: 35451104
pmcid: 9324935
doi: 10.1111/jcpe.13630
Mumcu G, Ergun T, Inanc Na, et al. Oral health is impaired in Behçet’s disease and is associated with disease severity. Rheumatology. 2004;43:1028–33.
pubmed: 15161982
doi: 10.1093/rheumatology/keh236
Coit P, Mumcu G, Ture-Ozdemir F, et al. Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behçet’s disease. Clin Immunol. 2016;169:28–35.
pubmed: 27283393
doi: 10.1016/j.clim.2016.06.002
Seoudi N, Bergmeier LA, Drobniewski F, Paster B, Fortune F. The oral mucosal and salivary microbial community of Behçet’s syndrome and recurrent aphthous stomatitis. J Oral Microbiol. 2015;7:27150.
pubmed: 26037240
doi: 10.3402/jom.v7.27150
Çelenligil-Nazliel H, Kansu E, Ebersole JL. Periodontal findings and systemic antibody responses to oral microorganisms in Behçet’s disease. J Periodontol. 1999;70:1449–56.
pubmed: 10632520
doi: 10.1902/jop.1999.70.12.1449
Hirschfeld J, Higham J, Chatzistavrianou D, Blair F, Richards A, Chapple IL. Systemic disease or periodontal disease? Distinguishing causes of gingival inflammation: a guide for dental practitioners. Part 1: immune-mediated, autoinflammatory, and hereditary lesions. Br Dent J. 2019;227:961–6.
pubmed: 31844223
doi: 10.1038/s41415-019-1050-8
Karadag O, Bolek EC. Management of Behcet’s syndrome. Rheumatology. 2020;59(Supplement3):iii108–117.
pubmed: 32348509
doi: 10.1093/rheumatology/keaa086
Akdeniz N, Esrefoglu M, Keles M, Karakuzu A, Atasoy M. Serum interleukin-2, interleukin-6, tumour necrosis factor-alpha and nitric oxide levels in patients with Behçet’s disease. Annals Acad Med Singap. 2004;33:596–9.
doi: 10.47102/annals-acadmedsg.V33N5p596