Impact of postoperative necrotizing enterocolitis after neonatal cardiac surgery on neurodevelopmental outcome at 1 year of age.

cardiopulmonary bypass surgery complications congenital heart disease neonates neurodevelopmental outcome

Journal

Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492

Informations de publication

Date de publication:
2024
Historique:
received: 01 02 2024
accepted: 02 07 2024
medline: 21 8 2024
pubmed: 21 8 2024
entrez: 21 8 2024
Statut: epublish

Résumé

We analyzed the impact of postoperative necrotizing enterocolitis (NEC) after cardiac surgery in neonatal age on neurodevelopmental (ND) outcome at 1 year of age. Using data from the Swiss Neurodevelopmental Outcome Registry for Children with Congenital Heart Disease (ORCHID), we analyzed perioperative variables including postoperative NEC (Bell's stage ≥2) and 1-year ND outcome (Bayley III). The included patients ( Postoperative NEC is associated with longer ICU and hospital LOS and contributes together with other complications to impaired ND outcome at 1 year of age. In the future, national and international patient registries may provide the opportunity to analyze large cohorts and better identify the impact of modifiable perioperative risk factors on ND outcome. ClinicalTrials.gov identifier: NCT05996211.

Identifiants

DOI: 10.3389/fped.2024.1380582 PMID: 39165487 PMC: PMC11333328
pubmed: 39165487
doi: 10.3389/fped.2024.1380582
pmc: PMC11333328
doi:

Banques de données

ClinicalTrials.gov
['NCT05996211']

Types de publication

Journal Article

Langues

eng

Pagination

1380582

Investigateurs

Nicole Sekarski (N)
Julia C Natterer (JC)
Juliane Schneider (J)
Christelle L'Ebraly (C)
Rene Pretre (R)
Amir-Reza Hosseinpour (AR)
Maya S Bouhabib (MS)
Angelo Polito (A)
Cristina Borradori-Tolsa (C)
Tornike Sologashvili (T)
Damian Hutter (D)
Lena Kaiser (L)
Marc Raphael Pfluger (MR)
Martin Glöckler (M)
Katharina Fuhrer-Kradolfer (K)
Sebastian Grunt (S)
Therese Fahrni (T)
Alexander Kadner (A)
Walter Knirsch (W)
Michael von Rhein (M)
Ruth Etter (R)
Verena Rathke (V)
Janet F Kelly-Geyer (JF)
Beatrice Latal (B)
Hitendu Dave (H)
Robert Cesnjevar (R)
Mark Brotzmann (M)
Hannah Kümin (H)
Rachel Kusche (R)
Christa Killer (C)
Ursula Speckle (U)
Regula Schmid (R)
Barbara Goeggel-Simonetti (B)
Letizia von Laer (L)
Seraina Calonder Faas (SC)
Margreet Duetz (M)
Marc Ecoffey (M)
Marie Pascale Metrailler (MP)
David Wille (D)
Berenice Bubl (B)

Informations de copyright

© 2024 Knirsch, De Silvestro, Rathke, L'Ebraly, Natterer, Schneider, Sekarski, Latal, Borradori-Tolsa, Bouhabib, Fuhrer Kradolfer, Glöckler, Hutter, Pfluger, Kaiser, Polito, Kelly-Geyer, von Rhein and the Swiss ORCHID group.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Walter Knirsch (W)

Pediatric Cardiology, Pediatric Heart Center, Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Alexandra De Silvestro (A)

Pediatric Cardiology, Pediatric Heart Center, Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Verena Rathke (V)

Pediatric Cardiology, Pediatric Heart Center, Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Christelle L'Ebraly (C)

Pediatric Cardiology, Woman-Mother-Child Department, University Hospital Lausanne, Lausanne, Switzerland.
Pediatric Cardiology, Woman-Child-Adolescent Department, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Julia C Natterer (JC)

Pediatric Intensive Care Unit, Woman-Mother-Child Department, University Hospital Lausanne, Lausanne, Switzerland.

Juliane Schneider (J)

Neonatology, Woman-Mother-Child Department, University Hospital Lausanne, Lausanne, Switzerland.

Nicole Sekarski (N)

Pediatric Cardiology, Woman-Mother-Child Department, University Hospital Lausanne, Lausanne, Switzerland.

Beatrice Latal (B)

Child Development Center, Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Cristina Borradori-Tolsa (C)

Development and Growth, Department of Pediatrics, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Maya S Bouhabib (MS)

Pediatric Cardiology, Woman-Child-Adolescent Department, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Katharina Fuhrer Kradolfer (K)

Pediatric Neurology, Bern, Switzerland.

Martin Glöckler (M)

Pediatric Cardiology, Center for Congenital Heart Disease, Department of Cardiology and Cardiac Surgery, University Children's Hospital, University of Bern, Bern, Switzerland.

Damian Hutter (D)

Pediatric Cardiology, Center for Congenital Heart Disease, Department of Cardiology and Cardiac Surgery, University Children's Hospital, University of Bern, Bern, Switzerland.

Marc R Pfluger (MR)

Pediatric Cardiology, Center for Congenital Heart Disease, Department of Cardiology and Cardiac Surgery, University Children's Hospital, University of Bern, Bern, Switzerland.

Lena Kaiser (L)

Pediatric Cardiology, Center for Congenital Heart Disease, Department of Cardiology and Cardiac Surgery, University Children's Hospital, University of Bern, Bern, Switzerland.

Angelo Polito (A)

Pediatric and Neonatal Intensive Care Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Janet F Kelly-Geyer (JF)

Department of Neonatology and Pediatric Intensive Care, Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Michael von Rhein (M)

Child Development Center, Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland.

Classifications MeSH