Sublingually administered bacterial lysates: rationale, mechanisms of action and clinical outcomes.
bacterial lysate
immunological mechanisms
sublingual administration
Journal
Drugs in context
ISSN: 1745-1981
Titre abrégé: Drugs Context
Pays: England
ID NLM: 101262187
Informations de publication
Date de publication:
2024
2024
Historique:
received:
22
01
2024
accepted:
12
06
2024
medline:
21
8
2024
pubmed:
21
8
2024
entrez:
21
8
2024
Statut:
epublish
Résumé
This review discusses available evidence on the mechanisms of action of bacterial lysates, and the clinical effects of their sublingual administration. Bacterial lysates act through many immunological effects, including dendritic cell activation, modification of circulating lymphocyte subsets and antibody production. The production of salivary IgA was repeatedly shown to be induced by the sublingual administration of a prototype bacterial lysate containing soluble and corpuscular antigens. Bacterial lysates are a useful tool for the prevention of recurrent respiratory tract infections. Sublingual administration should be the preferred option.
Identifiants
pubmed: 39165613
doi: 10.7573/dic.2024-1-5
pii: dic-2024-1-5
pmc: PMC11335356
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Informations de copyright
Copyright © 2024 Braido F, Melioli G, Nicolini G, Ferraris M, Di Girolamo S, Di Gioacchino M, Canonica GW.
Déclaration de conflit d'intérêts
Disclosure and potential conflicts of interest: GN is the Medical Director of Bruschettini srl, Genova, Italy; GM and FB act as consultant advisors of Bruschettini srl, Genova, Italy; SDG, MDG, MF and GWC have no competing interests. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at: https://www.drugsincontext.com/wp-content/uploads/2024/06/dic.2024-1-5-COI.pdf