Relationship of Subendocardial Perfusion to Myocardial Injury, Cardiac Structure, and Clinical Outcomes Among Patients With Hypertension.

heart failure hypertensive heart disease subendocardial ischemia

Journal

Circulation
ISSN: 1524-4539
Titre abrégé: Circulation
Pays: United States
ID NLM: 0147763

Informations de publication

Date de publication:
21 Aug 2024
Historique:
medline: 21 8 2024
pubmed: 21 8 2024
entrez: 21 8 2024
Statut: aheadofprint

Résumé

Coronary microvascular dysfunction has been implicated in the development of hypertensive heart disease and heart failure, with subendocardial ischemia identified as a driver of sustained myocardial injury and fibrosis. We aimed to evaluate the relationships of subendocardial perfusion with cardiac injury, structure, and a composite of major adverse cardiovascular and cerebral events consisting of death, heart failure hospitalization, myocardial infarction, and stroke. Layer-specific blood flow and myocardial flow reserve (MFR; stress/rest myocardial blood flow) were assessed by Among 358 patients, the mean age was 70.6±12.0 years, and 53.4% were male. The median MFR Among patients with hypertension without flow-limiting coronary artery disease, impaired MFR

Sections du résumé

BACKGROUND UNASSIGNED
Coronary microvascular dysfunction has been implicated in the development of hypertensive heart disease and heart failure, with subendocardial ischemia identified as a driver of sustained myocardial injury and fibrosis. We aimed to evaluate the relationships of subendocardial perfusion with cardiac injury, structure, and a composite of major adverse cardiovascular and cerebral events consisting of death, heart failure hospitalization, myocardial infarction, and stroke.
METHODS UNASSIGNED
Layer-specific blood flow and myocardial flow reserve (MFR; stress/rest myocardial blood flow) were assessed by
RESULTS UNASSIGNED
Among 358 patients, the mean age was 70.6±12.0 years, and 53.4% were male. The median MFR
CONCLUSIONS UNASSIGNED
Among patients with hypertension without flow-limiting coronary artery disease, impaired MFR

Identifiants

DOI: 10.1161/CIRCULATIONAHA.123.067083 PMID: 39166326
pubmed: 39166326
doi: 10.1161/CIRCULATIONAHA.123.067083
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Xiaolei Xu (X)

Zhejiang University School of Medicine, Hangzhou, China (X.X., L.Z.).
Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
Department of Cardiology, and Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (X.X., L.Z.).
ORCID: 0000-0003-3168-4743

Sanjay Divakaran (S)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
Heart and Vascular Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (S. Divakaran, B.N.W., R.B., J.M.B., M.F.D.C.).
ORCID: 0000-0003-0598-6502

Brittany N Weber (BN)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
Heart and Vascular Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (S. Divakaran, B.N.W., R.B., J.M.B., M.F.D.C.).
ORCID: 0000-0002-0177-2091

Jon Hainer (J)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
ORCID: 0000-0002-0572-912X

Shelby S Laychak (SS)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).

Benjamin Auer (B)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
ORCID: 0000-0003-0853-5651

Marie F Kijewski (MF)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
ORCID: 0000-0001-8365-1447

Ron Blankstein (R)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
Heart and Vascular Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (S. Divakaran, B.N.W., R.B., J.M.B., M.F.D.C.).
ORCID: 0000-0002-8393-6562

Sharmila Dorbala (S)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
ORCID: 0000-0003-1462-1185

Ludovic Trinquart (L)

Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA (L.T.).
Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA (L.T.).

Piotr Slomka (P)

Division of Artificial Intelligence, Department of Medicine, Cedars-Sinai, Los Angeles, CA (P.S.).
ORCID: 0000-0002-6110-938X

Li Zhang (L)

Zhejiang University School of Medicine, Hangzhou, China (X.X., L.Z.).
Department of Cardiology, and Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (X.X., L.Z.).
ORCID: 0000-0002-6906-3275

Jenifer M Brown (JM)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
Heart and Vascular Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (S. Divakaran, B.N.W., R.B., J.M.B., M.F.D.C.).
ORCID: 0000-0002-6647-639X

Marcelo F Di Carli (MF)

Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (X.X., S. Divakaran, B.N.W., J.H., S.S.L., B.A., M.F.K., R.B., S. Dorbala, J.M.B., M.F.D.C.).
Heart and Vascular Center, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. (S. Divakaran, B.N.W., R.B., J.M.B., M.F.D.C.).
ORCID: 0000-0003-3119-025X

Classifications MeSH