Theory of Mind Abilities May Predict Treatment Outcomes in Adolescents With Obsessive-Compulsive Disorder: A Follow-Up Study.

OCD adolescents cognitive flexibility predictors of response theory of mind

Journal

Early intervention in psychiatry
ISSN: 1751-7893
Titre abrégé: Early Interv Psychiatry
Pays: Australia
ID NLM: 101320027

Informations de publication

Date de publication:
21 Aug 2024
Historique:
revised: 08 07 2024
received: 07 05 2024
accepted: 08 08 2024
medline: 21 8 2024
pubmed: 21 8 2024
entrez: 21 8 2024
Statut: aheadofprint

Résumé

Researchers report varying levels of cognitive flexibility and theory of mind (ToM) deficiencies in adolescents with obsessive-compulsive disorder (OCD). This research set out to investigate the impact of these variables on the disorder's outcomes. The study involved 39 adolescents with OCD and 40 healthy controls. We assessed the case group at the initial visit to the outpatient clinic and again at the end of the first year of treatment. The Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) was applied to assess OCD symptom distribution and severity. The Reading the Mind in the Eyes of Children Test (RME-CT) was applied to evaluate ToM skills, and the Cognitive Flexibility Scale (CFS) was employed to evaluate cognitive flexibility levels. Baseline RME-CT and CFS scores were significantly lower in adolescents with OCD compared to the control group (p = 0.002 p = 0.001, respectively). At the end of the 1-year follow-up, RME-CT and CFS scores increased significantly in the adolescents with OCD (p < 0.001, p = 0.003, respectively). A significant negative correlation was observed between the initial RME-CT scores and the Y-BOCS scores at the end of the 1-year follow-up (p < 0.001). The initial RME-CT score had a significant negative predictive effect on the subsequent severity of OCD (β = -0.711, p < 0.001). The research revealed poorer long-term prognoses for OCD in adolescents who exhibit low ToM skills. In conclusion, the results indicate that ToM skills may serve as a predictive factor for long-term treatment outcomes among adolescents diagnosed with OCD.

Identifiants

pubmed: 39166714
doi: 10.1111/eip.13608
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 John Wiley & Sons Australia, Ltd.

Références

American Psychiatric Association (APA). 2022. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. text rev. ed. Arlington, VA: American Psychiatric Publishing. https://doi.org/10.1176/appi.books.9780890425787.
Baron‐Cohen, S., S. Wheelwright, J. Hill, Y. Raste, and I. Plumb. 2001. “The ‘Reading the Mind in the Eyes’ Test Revised Version: A Study With Normal Adults, and Adults With Asperger Syndrome or High‐Functioning Autism.” Journal of Child Psychology and Psychiatry, and Allied Disciplines 42, no. 2: 241–251. https://doi.org/10.1111/1469‐7610.00715.
Bobrowicz, K., and J. P. Thibaut. 2023. “The Development of Flexible Problem Solving: An Integrative Approach.” Journal of Intelligence 11, no. 6: 119. https://doi.org/10.3390/jintelligence11060119.
Bora, E. 2022. “Social Cognition and Empathy in Adults With Obsessive Compulsive Disorder: A Meta‐Analysis.” Psychiatry Research 316: 114752. https://doi.org/10.1016/j.psychres.2022.11475.
Carlson, S. M., L. J. Claxton, and L. J. Moses. 2015. “The Relation Between Executive Function and Theory of Mind Is More Than Skin Deep.” Journal of Cognition and Development 16, no. 1: 186–197. https://doi.org/10.1080/15248372.2013.824883.
Çelikkaleli, Ö. 2014. “The Validity and Reliability of the Cognitive Flexibility Scale.” Education and Science 39, no. 176: 339–346. https://doi.org/10.15390/EB.2014.3466.
Cervin, M. 2023. “Obsessive‐Compulsive Disorder: Diagnosis, Clinical Features, Nosology, and Epidemiology.” The Psychiatric Clinics of North America 46, no. 1: 1–16. https://doi.org/10.1016/j.psc.2022.10.006.
Chamberlain, S. R., J. E. Solly, R. W. Hook, M. M. Vaghi, and T. W. Robbins. 2021. “Cognitive Inflexibility in OCD and Related Disorders.” Current Topics in Behavioral Neurosciences 49: 125–145. https://doi.org/10.1007/7854_2020_198.
Champagne‐Lavau, M., A. Charest, K. Anselmo, J. P. Rodriguez, and G. Blouin. 2012. “Theory of Mind and Context Processing in Schizophrenia: The Role of Cognitive Flexibility.” Psychiatry Research 200, no. 2–3: 184–192. https://doi.org/10.1016/j.psychres.2012.06.011.
Dağdelen, F., and A. P. Vural. 2019. “Theory of Mind Skills in Adolescents With Obsessive Compulsive Disorder.” Psychiatry and Behavioral Sciences 9, no. 4: 172–178. https://doi.org/10.5455/PBS.20181101045321.
Farrant, B. M., J. Fletcher, and M. T. Maybery. 2014. “Cognitive Flexibility, Theory of Mind, and Hyperactivity/Inattention.” Child Development Research 2014: 741543. https://doi.org/10.1155/2014/741543.
Fineberg, N. A., A. M. Apergis‐Schoute, M. M. Vaghi, et al. 2018. “Mapping Compulsivity in the DSM‐5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment.” International Journal of Neuropsychopharmacology 21, no. 1: 42–58. https://doi.org/10.1093/ijnp/pyx088.
Francazio, S. K., and C. A. Flessner. 2015. “Cognitive Flexibility Differentiates Young Adults Exhibiting Obsessive‐Compulsive Behaviors From Controls.” Psychiatry Research 228, no. 2: 185–190. https://doi.org/10.1016/j.psychres.2015.04.038.
Girli, A. 2014. “Psychometric Properties of the Turkish Child and Adult Form of ‘Reading the Mind in the Eyes Test’.” Psychology 5, no. 11: 1321–1337. https://doi.org/10.4236/psych.2014.511143.
Goodman, W. K., L. H. Price, S. A. Rasmussen, et al. 1989. “The Yale‐Brown Obsessive Compulsive Scale. I. Development, Use, and Reliability.” Archives of General Psychiatry 46, no. 11: 1006–1011. https://doi.org/10.1001/archpsyc.1989.01810110048007.
Greenberg, D. M., V. Warrier, A. Abu‐Akel, et al. 2023. “Sex and Age Differences in ‘Theory of Mind’ Across 57 Countries Using the English Version of the ‘Reading the Mind in the Eyes’ Test.” Proceedings of the National Academy of Sciences of the United States of America 120, no. 1: e2022385119. https://doi.org/10.1073/pnas.2022385119.
Grisham, J. R., J. D. Henry, A. D. Williams, and P. E. Bailey. 2010. “Socioemotional Deficits Associated With Obsessive‐Compulsive Symptomatology.” Psychiatry Research 175, no. 3: 256–259. https://doi.org/10.1016/j.psychres.2009.01.028.
Gruner, P., and C. Pittenger. 2017. “Cognitive Inflexibility in Obsessive‐Compulsive Disorder.” Neuroscience 345: 243–255. https://doi.org/10.1016/j.neuroscience.2016.07.030.
Jansen, M., S. Overgaauw, and E. R. A. De Bruijn. 2020. “Social Cognition and Obsessive‐Compulsive Disorder: A Review of Subdomains of Social Functioning.” Frontiers in Psychiatry 11: 118. https://doi.org/10.3389/fpsyt.2020.00118.
2012. “Practice Parameter for the Assessment and Treatment of Children and Adolescents With Obsessive‐Compulsive Disorder.” Journal of the American Academy of Child and Adolescent Psychiatry 51, no. 1: 98–113. https://doi.org/10.1016/j.jaac.2011.09.019.
Krebs, G., and I. Heyman. 2015. “Obsessive‐Compulsive Disorder in Children and Adolescents.” Archives of Disease in Childhood 100, no. 5: 495–499. https://doi.org/10.1136/archdischild‐2014‐306934.
López‐Del‐Hoyo, Y., M. G. Panzano, G. Lahera, et al. 2019. “Differences Between Individuals With Schizophrenia or Obsessive‐Compulsive Disorder and Healthy Controls in Social Cognition and Mindfulness Skills: A Controlled Study.” PLoS One 14, no. 12: e0225608. https://doi.org/10.1371/journal.pone.0225608.
Martin, M. M., and R. B. Rubin. 1995. “A New Measure of Cognitive Flexibility.” Psychological Reports 76, no. 2: 623–626. https://doi.org/10.2466/pr0.1995.76.2.623.
Mizrahi, R., M. Korostil, S. E. Starkstein, R. B. Zipursky, and S. Kapur. 2007. “The Effect of Antipsychotic Treatment on Theory of Mind.” Psychological Medicine 37, no. 4: 595–601. https://doi.org/10.1017/S0033291706009342.
Molenberghs, P., H. Johnson, J. D. Henry, and J. B. Mattingley. 2016. “Understanding the Minds of Others: A Neuroimaging Meta‐Analysis.” Neuroscience and Biobehavioral Reviews 65: 276–291. https://doi.org/10.1016/j.neubiorev.2016.03.020.
Ng, R., S. Fish, and E. Granholm. 2015. “Insight and Theory of Mind in Schizophrenia.” Psychiatry Research 225, no. 1–2: 169–174. https://doi.org/10.1016/j.psychres.2014.11.010.
Öztürk, Y., G. Özyurt, S. Turan, A. E. Tufan, and A. P. Akay. 2023. “Emotion Dysregulation and Social Communication Problems but Not ToM Properties May Predict Obsessive‐Compulsive Disorder Symptom Severity.” Nordic Journal of Psychiatry 77, no. 8: 778–787. https://doi.org/10.1080/08039488.2023.2251953.
Pino, M. C., D. De Berardis, M. Mariano, et al. 2016. “Two Systems for Empathy in Obsessive‐Compulsive Disorder: Mentalizing and Experience Sharing.” Revista Brasileira de Psiquiatria (Sao Paulo, Brazil: 1999) 38, no. 4: 307–313. https://doi.org/10.1590/1516‐4446‐2015‐1679.
Sami, H., S. Tei, H. Takahashi, and J. Fujino. 2023. “Association of Cognitive Flexibility With Neural Activation During the Theory of Mind Processing.” Behavioural Brain Research 443: 114332. https://doi.org/10.1016/j.bbr.2023.114332.
Sayin, A., N. Oral, C. Utku, E. Baysak, and S. Candansayar. 2010. “Theory of Mind in Obsessive‐Compulsive Disorder: Comparison With Healthy Controls.” European Psychiatry: The Journal of the Association of European Psychiatrists 25, no. 2: 116–122. https://doi.org/10.1016/j.eurpsy.2009.09.002.
Schulte‐Rüther, M., V. Mainz, G. R. Fink, B. Herpertz‐Dahlmann, and K. Konrad. 2012. “Theory of Mind and the Brain in Anorexia Nervosa: Relation to Treatment Outcome.” Journal of the American Academy of Child and Adolescent Psychiatry 51, no. 8: 832–841. https://doi.org/10.1016/j.jaac.2012.06.007.
Stewart, S. E., D. A. Geller, M. Jenike, et al. 2004. “Long‐Term Outcome of Pediatric Obsessive‐Compulsive Disorder: A Meta‐Analysis and Qualitative Review of the Literature.” Acta Psychiatrica Scandinavica 110, no. 1: 4–13. https://doi.org/10.1111/j.1600‐0447.2004.00302.x.
Stiede, J. T., S. D. Spencer, O. Onyeka, et al. 2023. “Obsessive‐Compulsive Disorder in Children and Adolescents.” Annual Review of Clinical Psychology 20: 355–380. https://doi.org/10.1146/annurev‐clinpsy‐080822‐043910.
Tulacı, R. G., E. Ş. Cankurtaran, K. Özdel, N. Öztürk, E. Kuru, and İ. Özdemir. 2018. “The Relationship Between Theory of Mind and Insight in Obsessive‐Compulsive Disorder.” Nordic Journal of Psychiatry 72, no. 4: 273–280. https://doi.org/10.1080/08039488.2018.1436724.
Uhre, C. F., M. Ritter, J. R. M. Jepsen, et al. 2023. “Atypical Neurocognitive Functioning in Children and Adolescents With Obsessive‐Compulsive Disorder (OCD).” European Child & Adolescent Psychiatry 33: 2291–2300. https://doi.org/10.1007/s00787‐023‐02301‐w.
Yamada, K., Y. Inoue, and S. Kanba. 2015. “Theory of Mind Ability Predicts Prognosis of Outpatients With Major Depressive Disorder.” Psychiatry Research 230, no. 2: 604–608. https://doi.org/10.1016/j.psychres.2015.10.011.
Yazici, K. U., and I. P. Yazici. 2019. “Decreased Theory of Mind Skills, Increased Emotion Dysregulation and Insight Levels in Adolescents Diagnosed With Obsessive Compulsive Disorder.” Nordic Journal of Psychiatry 73, no. 7: 462–469. https://doi.org/10.1080/08039488.2019.1652341.
Yeung, E. K. L., I. A. Apperly, and R. T. Devine. 2023. “Measures of Individual Differences in Adult Theory of Mind: A Systematic Review.” Neuroscience and Biobehavioral Reviews 157: 105481. https://doi.org/10.1016/j.neubiorev.2023.105481.
Yucelen, A. G., A. Rodopman‐Arman, V. Topcuoglu, M. Y. Yazgan, and G. Fisek. 2006. “Interrater Reliability and Clinical Efficacy of Children's Yale‐Brown Obsessive‐Compulsive Scale in an Outpatient Setting.” Comprehensive Psychiatry 47, no. 1: 48–53. https://doi.org/10.1016/j.comppsych.2005.04.005.

Auteurs

Tayfun Kara (T)

Faculty of Medicine, Department of Child and Adolescent Psychiatry, Alanya Alaaddin Keykubat University, Antalya, Turkey.

Pınar Aydoğan Avşar (P)

Department of Child and Adolescent Psychiatry, Alanya Training and Research Hospital, Antalya, Turkey.

Tacettin Kuru (T)

Department of Psychiatry, Alanya Training and Research Hospital, Antalya, Turkey.

Orhan Kocaman (O)

Faculty of Medicine, Department of Child and Adolescent Psychiatry, Alanya Alaaddin Keykubat University, Antalya, Turkey.

Classifications MeSH